Meng Muzi, Choi Paul Joon Koo, Pydi Reshma, Farkas Daniel T
School of Medicine, American University of the Caribbean, Cupecoy, SXM.
General Surgery, BronxCare Health System, New York, USA.
Cureus. 2024 Jul 31;16(7):e65876. doi: 10.7759/cureus.65876. eCollection 2024 Jul.
Immune thrombocytopenic purpura (ITP) is a challenging condition to manage especially when conventional treatment methods, including splenectomy, fail. This report evaluates the effectiveness of laparoscopic removal of accessory spleen for chronic refractory ITP after an initial splenectomy. A 73-year-old African American male with a history of ITP, previously treated with laparoscopic splenectomy nine years ago, presented with severe thrombocytopenia that was found to be refractory to medical therapies. Platelet counts were monitored, and the absence of Howell-Jolly bodies was noted in the peripheral blood smear. Imaging studies over the past eight years indicated the growth of a mass in the left upper abdomen, suggesting a possible accessory spleen. Given the overwhelming evidence of a splenule in refractory thrombocytopenia, laparoscopic exploration and mass removal were conducted. Histologic analysis of the removed mass confirmed a splenule. Despite the complete removal of the mass, postoperative platelet counts remained consistently low and unresponsive to the resumption of medical therapies. This study emphasizes the limitations of accessory splenectomy for refractory ITP and highlights the need for further research to clarify the long-term effectiveness of this surgical procedure in these patients.
免疫性血小板减少性紫癜(ITP)是一种难以处理的病症,尤其是在包括脾切除术在内的传统治疗方法无效时。本报告评估了腹腔镜下切除副脾对初次脾切除术后慢性难治性ITP的疗效。一名73岁的非裔美国男性,有ITP病史,9年前曾接受腹腔镜脾切除术,现出现严重血小板减少,且对药物治疗无效。监测血小板计数,并在外周血涂片上未发现豪-焦小体。过去八年的影像学研究表明左上腹有一个肿块生长,提示可能存在副脾。鉴于难治性血小板减少症中存在副脾的压倒性证据,进行了腹腔镜探查和肿块切除。切除肿块的组织学分析证实为副脾。尽管肿块已完全切除,但术后血小板计数仍持续偏低,且对恢复药物治疗无反应。本研究强调了副脾切除术治疗难治性ITP的局限性,并突出了进一步研究以阐明该手术对这些患者长期疗效的必要性。