Cruz Dardiane Santos, Damasceno Renata Fiúza, Leite Sâmara Fernandes, Cardoso Mayra Domingues, Almeida Débora Natália Menezes, de Souza Andreia Brito, de Jesus Santos Ana Clara, Veira Thallyta Maria, Ribeiro Antônio Luiz Pinho, de Oliveira Léa Campos, Sabino Ester Cerdeira, Haikal Desirée Sant'Ana, Ferreira Ariela Mota, Molina Israel
Programa de Pós-graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brasil.
Superintendência Regional de Saúde de Montes Claros. Secretaria de Estado de Saúde de Minas Gerais, Minas Gerais, Brasil.
IJID Reg. 2024 Jul 9;12:100400. doi: 10.1016/j.ijregi.2024.100400. eCollection 2024 Sep.
Chagas disease (CD) is an infectious disease that predominantly affects poor and vulnerable populations. The last estimate conducted by the World Health Organization in Latin America regarding the prevalence of CD occurred more than 10 years ago. However, there is a scarcity of data assessing the magnitude of CD in populations residing in considered high-risk regions. Therefore, this study aimed to assess the seroprevalence of CD in an endemic region in Northern Minas Gerais through serologic screening.
This is a prevalence study conducted in the municipalities of Catuti, Mato Verde, Mirabela, Montes Azul, and São Francisco, Minas Gerais, Brazil. Data collection occurred between December 2021 and December 2022, involving a questionnaire with closed-ended questions. The variables analyzed included serologic test results, stratified age groups, health indicators, and housing conditions.
Of the 2978 participants, 272 individuals (9.1%) tested positive for CD serology. In the age group of 4 to 14 years, 15 to 49 years, and 50 years or older, the prevalence of positive serology was 0.8% (95% confidence interval [CI] 0.16-1.43), 5.5% (95% CI 4.20-6.83), and 18.8% (95% CI 16.48-21.11), respectively. Among the participating municipalities, Mato Verde had the highest prevalence of positive serology for CD (17%). For participants aged 4 to 14 years with positive serology for CD, first-degree relatives were invited to undergo serologic testing. It was possible to collect samples from relatives of all participants in this age group. However, none of the relatives tested positive.
This study identified a 9.1% prevalence of individuals affected by CD who were unaware of their condition. In addition, having infected children in the 4 to 14 age group with mothers with negative serology would rule out congenital transmission of the disease.
恰加斯病（CD）是一种主要影响贫困和弱势群体的传染病。世界卫生组织上次对拉丁美洲恰加斯病患病率进行的估计是在10多年前。然而，在被视为高风险地区的居民中，评估恰加斯病规模的数据稀缺。因此，本研究旨在通过血清学筛查评估米纳斯吉拉斯州北部一个流行地区恰加斯病的血清阳性率。
这是一项在巴西米纳斯吉拉斯州卡图蒂、马托韦尔德、米拉贝拉、蒙特斯阿祖尔和圣弗朗西斯科等市进行的患病率研究。数据收集于2021年12月至2022年12月期间进行，涉及一份有封闭式问题的问卷。分析的变量包括血清学检测结果、分层年龄组、健康指标和住房条件。
在2978名参与者中，272人（9.1%）恰加斯病血清学检测呈阳性。在4至14岁、15至49岁和50岁及以上年龄组中，血清学阳性患病率分别为0.8%（95%置信区间[CI]0.16 - 1.43）、5.5%（95%CI 4.20 - 6.83）和18.8%（95%CI 16.48 - 21.11）。在参与研究的各市中，马托韦尔德恰加斯病血清学阳性患病率最高（17%）。对于恰加斯病血清学阳性的4至14岁参与者，邀请其一级亲属进行血清学检测。有可能收集该年龄组所有参与者亲属的样本。然而，没有亲属检测呈阳性。
本研究发现9.1%的恰加斯病患者未意识到自己的病情。此外，4至14岁年龄组的感染儿童其母亲血清学呈阴性，可排除该病的先天性传播。
