Griffith T M, Edwards D H, Lewis M J, Henderson A H
Adv Myocardiol. 1985;6:137-53.
Using an isolated perfused coronary-artery preparation, we have demonstrated the ability of endothelium inhibit markedly to vasomotion in rabbit coronary arteries. Using a bioassay system, we have shown this effect to be mediated via the release of an unstable humoral agent (t 1/2 approximately equal to 6 sec) from endothelial cells, and we have partially characterized its chemical nature.
利用离体灌注冠状动脉制备技术,我们已证明内皮细胞能显著抑制兔冠状动脉的血管运动。通过生物测定系统,我们发现这种效应是由内皮细胞释放一种不稳定的体液因子(半衰期约为6秒)介导的,并且我们已对其化学性质进行了部分表征。