Wen Qian-Er, Li Liang, Feng Rui-Qi, Li De-Hui, Qiao Chang, Xu Xiao-Song, Zhang Yan-Jing
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People's Republic of China.
Oncology Department II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Shijiazhuang, Hebei Province, People's Republic of China.
Breast Cancer (Dove Med Press). 2024 Aug 27;16:497-516. doi: 10.2147/BCTT.S482504. eCollection 2024.
Breast cancer is one of the most common malignant tumors in women in the world, and its incidence is increasing year by year, which seriously threatens the physical and mental health of women. Triple negative breast cancer (TNBC) is a special molecular type of breast cancer in which estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 are negative. Compared with other molecular types of breast cancer, triple-negative breast cancer (TNBC) has high aggressiveness and metastasis, high recurrence rate, lack of effective therapeutic targets, and usually poor clinical treatment effect. Chemotherapy was the main therapeutic means used in the past. With the advent of the immune era, immunotherapy has made a lot of progress in the treatment of triple-negative breast cancer (TNBC), bringing new therapeutic hope for the treatment of triple-negative breast cancer. This review combines the results of cutting-edge medical research, mainly summarizes the research progress of immunotherapy, and summarizes the main treatment methods of triple-negative breast cancer (TNBC) immunotherapy, including immune checkpoint inhibitors, tumor vaccines, adoptive immunotherapy and the application of traditional Chinese and western medicine. It provides a new idea for the treatment of triple negative breast cancer (TNBC).
乳腺癌是全球女性中最常见的恶性肿瘤之一，其发病率逐年上升，严重威胁着女性的身心健康。三阴性乳腺癌（TNBC）是一种特殊分子类型的乳腺癌，其中雌激素受体、孕激素受体和人表皮生长因子受体2均为阴性。与其他分子类型的乳腺癌相比，三阴性乳腺癌（TNBC）具有高侵袭性和转移性、高复发率、缺乏有效的治疗靶点，且临床治疗效果通常较差。化疗是过去主要使用的治疗手段。随着免疫时代的到来，免疫疗法在三阴性乳腺癌（TNBC）的治疗中取得了很大进展，为三阴性乳腺癌的治疗带来了新的治疗希望。本综述结合前沿医学研究成果，主要总结免疫疗法的研究进展，并概述三阴性乳腺癌（TNBC）免疫疗法的主要治疗方法，包括免疫检查点抑制剂、肿瘤疫苗、过继性免疫疗法以及中西医结合的应用。它为三阴性乳腺癌（TNBC）的治疗提供了新思路。
