Li De-Hui, Wen Qian-Er, Feng Rui-Qi, Qiao Chang, Tian Xiao-Tong
Department of Oncology II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang 050000, Hebei Province, China.
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050000, Hebei Province, China.
World J Gastrointest Oncol. 2024 Dec 15;16(12):4770-4777. doi: 10.4251/wjgo.v16.i12.4770.
This manuscript used network pharmacology and experimental verification to analyze the anti-hepatocarcinoma mechanism of action of bezoars in traditional Chinese medicine (TCM), discovering that it can affect the immune cells within the tumor microenvironment and related pathways to produce inhibitory effects in liver cancer. In TCM, bezoars have a unique therapeutic advantage in the prevention and treatment of tumors. They play an anti-tumorigenic role by regulating the immune microenvironment through multi-component, multi-target and multi-pathway mechanisms. With the application of nanotechnology, bezoars and their compound preparations have been developed into anti-cancer drugs with unique therapeutic advantages, providing novel treatment options for tumor patients.
本手稿运用网络药理学和实验验证方法，分析了中药牛黄抗肝癌的作用机制，发现其可影响肿瘤微环境中的免疫细胞及相关通路，从而对肝癌产生抑制作用。在中医领域，牛黄在肿瘤防治方面具有独特的治疗优势。它们通过多成分、多靶点、多途径机制调节免疫微环境，发挥抗肿瘤作用。随着纳米技术的应用，牛黄及其复方制剂已被开发成具有独特治疗优势的抗癌药物，为肿瘤患者提供了新的治疗选择。
