Li Mingzhu, Zhu Xudong, Zhang Mingxue, Yu Jun, Jin Shengbo, Hu Xiaoli, Piao Haozhe
Department of Integrated Traditional Chinese and Western Medicine Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, P.R. China.
Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, P.R. China.
Open Life Sci. 2024 Aug 29;19(1):20220905. doi: 10.1515/biol-2022-0905. eCollection 2024.
Pain has been a prominent medical concern since ancient times. Despite significant advances in the diagnosis and treatment of pain in contemporary medicine, there is no a therapeutic cure for chronic pain. Chinese herbaceous peony, a traditional Chinese analgesic herb has been in clinical use for millennia, with widespread application and substantial efficacy. Paeoniflorin (PF), the main active ingredient of Chinese herbaceous peony, has antioxidant, anti-inflammatory, anticancer, analgesic, and antispasmodic properties, among others. The analgesic effect of PF, involving multiple critical targets and pain regulatory pathways, has been a hot spot for current research. This article reviews the literature related to the analgesic effect of PF in the past decade and discusses the molecular mechanism of the analgesic effect of PF, including the protective effects of nerve cells, inhibition of inflammatory reactions, antioxidant effects, reduction of excitability in nociceptor, inhibition of the nociceptive excitatory neuroreceptor system, activation of the nociceptive inhibitory neuroreceptor system and regulation of other receptors involved in nociceptive sensitization. Thus, providing a theoretical basis for pain prevention and treatment research. Furthermore, the prospect of PF-based drug development is presented to propose new ideas for clinical analgesic therapy.
自古以来，疼痛一直是医学关注的重点问题。尽管当代医学在疼痛的诊断和治疗方面取得了重大进展，但慢性疼痛仍无治愈方法。白芍是一种传统的中药止痛草药，已在临床应用了数千年，应用广泛且疗效显著。芍药苷（PF）是白芍的主要活性成分，具有抗氧化、抗炎、抗癌、止痛和解痉等特性。PF的止痛作用涉及多个关键靶点和疼痛调节途径，一直是当前研究的热点。本文回顾了过去十年中与PF止痛作用相关的文献，并探讨了PF止痛作用的分子机制，包括对神经细胞的保护作用、对炎症反应的抑制作用、抗氧化作用、降低伤害感受器的兴奋性、抑制伤害性兴奋神经受体系统、激活伤害性抑制神经受体系统以及对参与伤害性致敏的其他受体的调节作用。从而为疼痛防治研究提供理论依据。此外，还介绍了基于PF的药物开发前景，为临床止痛治疗提出新思路。
