Lastialno Mohammad Parezal, Bashari Muhammad Hasan, Ariyanto Eko Fuji
Program of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 40161, Indonesia.
Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, 45363, Indonesia.
Diabetes Metab Syndr Obes. 2024 Aug 27;17:3177-3186. doi: 10.2147/DMSO.S471348. eCollection 2024.
Obesity is a condition in which there is an accumulation of excess body fat leading to a weight far above the normal range that poses significant health risks. According to WHO, 8 billion people in the world were obese in 2022. Consequently, obesity has become a pandemic with negative impacts on both global health and economies. Obesity is influenced by various factors including environmental influences, lifestyle choices, gut microbiota, genetic factors, and epigenetic mechanisms such as DNA methylation. DNA methylation can affect an individual's phenotype and condition without altering their DNA sequence. It is the most extensively studied epigenetic alteration and it plays an important part in controlling gene activity associated with obesity. Numerous studies have indicated that DNA methylation is implicated in obesity, thus this review aims to elaborate the roles of DNA methylation to inform the development of preventive measures for obesity.
肥胖是一种体内脂肪过度堆积，导致体重远超正常范围，并带来重大健康风险的状况。据世界卫生组织称，2022年全球有80亿人肥胖。因此，肥胖已成为一种对全球健康和经济都有负面影响的流行病。肥胖受多种因素影响，包括环境影响、生活方式选择、肠道微生物群、遗传因素以及DNA甲基化等表观遗传机制。DNA甲基化可在不改变个体DNA序列的情况下影响其表型和健康状况。它是研究最广泛的表观遗传改变，在控制与肥胖相关的基因活性方面发挥着重要作用。大量研究表明DNA甲基化与肥胖有关，因此本综述旨在阐述DNA甲基化的作用，为肥胖预防措施的制定提供信息。
