Sofi Mohmmad Ashaq, Sofi Mohd Abass, Nanda Anima, Thiruvengadam Kasi, Nayak B K
Department of Biomedical Engineering Sathyabama Institute of Science & Technology, Chennai 600119, Tamil Nadu, India.
Department of Chemistry Sathyabama Institute of Science & Technology, Chennai 600119, Tamil Nadu, India.
Adv Pharmacol Pharm Sci. 2024 Aug 24;2024:5301687. doi: 10.1155/2024/5301687. eCollection 2024.
This study investigated the medicinal potential of , a plant traditionally known for its therapeutic properties. The aim was to identify the phytocompounds in leaf extract and evaluate its antibacterial, antioxidant, and anticancer effects. Gas chromatography-mass spectrometry analysis was employed to characterize the phytochemical composition of the ethanol extract derived from leaves. The antimicrobial potential was assessed through the well diffusion technique, targeting , , , , and . The 2,2-diphenyl-1-picrylhydrazyl assay was conducted to assess antioxidant capabilities, while cytotoxicity against the A549 cancer cell line was determined via the MTT assay. GC-MS analysis identified ten different compounds, with phytol, 1-Eicosanol, and 2,6,10-trimethyl,14-ethylene-14-pentadecne being the most prevalent. The extract exhibited notable antimicrobial efficacy against all bacteria with MIC values ranging from 62.5 to 250 g/mL. However, did not respond. The extract exhibited antioxidative properties with an IC value of 86 g/mL and cytotoxicity with an IC value of 69.95 g/mL against the A549 cancer cell line. The results derived from this study supported the historical use of as a medicinal plant and suggested that it can potentially treat a wide range of medical ailments. The identified phytocompounds and the demonstrated antibacterial, antioxidant, and anticancer effects provide scientific evidence for its medicinal properties. However, further investigations are needed to fully understand its safety profile, efficacy, and mechanism of action before recommending it for therapeutic purposes.
本研究调查了一种传统上因其治疗特性而闻名的植物的药用潜力。目的是鉴定该植物叶提取物中的植物化合物,并评估其抗菌、抗氧化和抗癌作用。采用气相色谱-质谱分析法对该植物叶乙醇提取物的植物化学成分进行表征。通过打孔扩散技术评估其抗菌潜力,目标细菌为[细菌名称1]、[细菌名称2]、[细菌名称3]、[细菌名称4]和[细菌名称5]。进行2,2-二苯基-1-苦基肼测定以评估抗氧化能力,同时通过MTT测定法确定对A549癌细胞系的细胞毒性。气相色谱-质谱分析鉴定出十种不同的化合物,其中叶绿醇、1-二十烷醇和2,6,10-三甲基-14-乙烯-14-十五碳烯最为普遍。该提取物对所有细菌均表现出显著的抗菌效果,最低抑菌浓度值范围为62.5至250μg/mL。然而,[细菌名称6]没有反应。该提取物表现出抗氧化特性,对A549癌细胞系的半数抑制浓度值为86μg/mL,细胞毒性的半数抑制浓度值为69.95μg/mL。本研究结果支持了该植物作为药用植物的历史用途,并表明它有可能治疗多种疾病。鉴定出的植物化合物以及所证明的抗菌、抗氧化和抗癌作用为其药用特性提供了科学证据。然而,在将其推荐用于治疗目的之前,还需要进一步研究以充分了解其安全性、疗效和作用机制。