Alenzi Maram, Almeqdadi Mohammad
Department of Medicine, St. Elizabeth's Medical Center, Boston University, MA 02135, United States.
Department of Transplant and Hepatobiliary Disease, Tufts Medical Center, Boston, MA 02111, United States.
World J Hepatol. 2024 Aug 27;16(8):1091-1098. doi: 10.4254/wjh.v16.i8.1091.
Hepatitis C virus (HCV) is a significant public health challenge globally, with substantial morbidity and mortality due to chronic liver disease. Despite the availability of highly effective and well-tolerated direct-acting antiviral therapies, widespread disparities remain in hepatitis C screening, access to treatment, linkage to care, and therapeutic outcomes. This review article synthesizes evidence from various studies to highlight the multifactorial nature of these disparities, which affects ethnic minorities, people with lower socioeconomic status, individuals with substance use disorders, and those within correctional facilities. The review also discusses policy implications and targeted strategies needed to overcome barriers and ensure equitable care for all individuals with HCV. Recommendations for future research to address gaps in knowledge and evaluation of the effectiveness of interventions designed to reduce disparities are provided.
丙型肝炎病毒(HCV)是全球重大的公共卫生挑战,因慢性肝病导致大量发病和死亡。尽管有高效且耐受性良好的直接抗病毒疗法,但在丙型肝炎筛查、治疗可及性、护理衔接以及治疗效果方面,广泛存在的差异依然存在。这篇综述文章综合了各项研究的证据,以突出这些差异的多因素性质,这些差异影响着少数族裔、社会经济地位较低的人群、患有物质使用障碍的个体以及惩教机构中的人员。该综述还讨论了政策影响以及克服障碍并确保为所有丙型肝炎患者提供公平护理所需的针对性策略。提供了关于未来研究的建议,以填补知识空白并评估旨在减少差异的干预措施的有效性。