Heidari Hamid, Khalaj Azam, Khani Sima, Abdollahi Maasoume, Farahani Hamid, Khani Samira
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Department of Chemistry, University of Massachusetts Boston, Boston, MA, USA.
Horm Mol Biol Clin Investig. 2022 May 2;43(3):289-296. doi: 10.1515/hmbci-2021-0050. eCollection 2022 Sep 1.
Hance, commonly known as lesser galangal, is a member of the ginger family (Zingiberaceae) traditionally used for many decades to treat inflammation, pain, stomach ache and cold. In the present study, the antidiabetic and hypolipidemic potentials of the hydroalcoholic extract of were investigated in the nicotinamide/streptozotocin induced type II diabetic rats.
Male Wistar rats were divided into following six groups: Group I was normal control rats. Group II: normal diabetic control, Group III: Diabetic rats treated with glibenclamide (0.25 mg/kg), IV, V and VI: Diabetic rats treated with 100, 200 and 500 mg/kg hydroalcoholic extract by daily gavage for 28 days, respectively. At the end of treatment, biochemical analysis, histological study, phytochemical analysis and acute toxicity tests were carried out.
The results show significant reduction in blood glucose, serum lipid profiles, and liver enzyme levels in diabetic rats compared with diabetic control in treated group.
In conclusion, the present study demonstrated that extract had significant (p<0.05) antidiabetic and anti-hyperlipidemia effects in addition to hepatoprotective effect in type II diabetic rats.
山姜，俗称小草蔻，是姜科（姜科）的一员，数十年来一直被传统用于治疗炎症、疼痛、胃痛和感冒。在本研究中，研究了山姜水醇提取物对烟酰胺/链脲佐菌素诱导的II型糖尿病大鼠的抗糖尿病和降血脂潜力。
将雄性Wistar大鼠分为以下六组：第一组为正常对照大鼠。第二组：正常糖尿病对照，第三组：用格列本脲（0.25mg/kg）治疗的糖尿病大鼠，第四组、第五组和第六组：分别用100、200和500mg/kg山姜水醇提取物每日灌胃28天的糖尿病大鼠。治疗结束时，进行生化分析、组织学研究、植物化学分析和急性毒性试验。
结果显示，与山姜治疗组的糖尿病对照相比，糖尿病大鼠的血糖、血清脂质谱和肝酶水平显著降低。
总之，本研究表明，山姜提取物对II型糖尿病大鼠除具有肝保护作用外，还具有显著（p<0.05）的抗糖尿病和抗高血脂作用。
