Nonwoven Technology Laboratory, Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, People's Republic of China.
ACS Appl Mater Interfaces. 2023 Apr 5;15(13):16515-16525. doi: 10.1021/acsami.3c01065. Epub 2023 Mar 23.
Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against and . Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.
具有抗菌、粘合和抗氧化活性的水凝胶伤口敷料在临床治疗皮肤损伤方面是理想的。本研究使用多巴胺（DA）和槲皮素（QT）设计并制备了一系列具有高粘合性、自修复、抗氧化和抗菌活性的多功能水凝胶伤口敷料。多功能水凝胶通过互穿的季铵化壳聚糖链段和聚丙烯酰胺网络构建。DA、QT 上的邻苯二酚基团和水凝胶系统中的季铵基团赋予水凝胶高强度、优异的附着力和自修复能力。结果证实了多功能水凝胶具有良好的血液相容性和对 和 的显著抗菌活性。因此，具有令人满意的粘合性和抗菌活性的多功能水凝胶是组织粘合剂和伤口敷料应用领域的合适替代材料。
