Cui Mingming, Zhang Jin, Han Pengfei, Shi Ling, Li Xing, Zhang Zhe, Bao Haihua, Ma Yubo, Tao Ziwei, Dong Xianghui, Fu Li, Wu Yan
Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
College of Life Science, Mudanjiang Medical University, Mudanjiang, 157011, China.
Mater Today Bio. 2024 Aug 6;28:101186. doi: 10.1016/j.mtbio.2024.101186. eCollection 2024 Oct.
Diabetic wounds pose a clinical challenge due to persistent inflammation, severe bacterial infections, inadequate vascularization, and pronounced oxidative stress. Current therapeutic modalities fail to provide satisfactory outcomes in managing these conditions, resulting in considerable patient distress. Two-dimensional nanomaterials (2DNMs), characterized by their unique nanosheet structures, expansive surface areas, and remarkable physicochemical properties, have garnered considerable attention for their potential in therapeutic applications. Emerging 2DNMs can be loaded with various pharmacological agents, including small molecules, metal ions, and liposomes. Moreover, they can be integrated with various biomaterials such as hydrogels, microneedles, and microspheres, thus demonstrating unprecedented advantages in expediting the healing process of diabetic wounds. Moreover, 2DNMs exhibit exceptional performance characteristics, including high biocompatibility, effective antimicrobial properties, optimal phototherapeutic effects, and enhanced electrostimulation capabilities. These properties enable them to modulate the wound microenvironment, leading to widespread application in tissue repair with remarkable outcomes. This review delineates several emerging 2DNMs, such as graphene and its derivatives, black phosphorus, MXenes, and transition metal dichalcogenides, in the context of diabetic wound repair. Furthermore, it elucidates the translational challenges and future perspectives of 2DNMs in wound healing treatments. Overall, 2DNMs present a highly promising strategy for ameliorating diabetic wounds, thus providing novel avenues for diagnostic and therapeutic strategies in diabetic wound management.
糖尿病伤口由于持续炎症、严重细菌感染、血管化不足和明显的氧化应激而构成临床挑战。目前的治疗方式在处理这些情况时未能提供令人满意的结果，给患者带来了相当大的痛苦。二维纳米材料（2DNMs）以其独特的纳米片结构、广阔的表面积和卓越的物理化学性质为特征，因其在治疗应用中的潜力而备受关注。新兴的2DNMs可以负载各种药物制剂，包括小分子、金属离子和脂质体。此外，它们可以与各种生物材料如 hydrogels、微针和微球整合，从而在加速糖尿病伤口愈合过程中展现出前所未有的优势。此外，2DNMs表现出卓越的性能特征，包括高生物相容性、有效的抗菌性能、最佳的光疗效果和增强的电刺激能力。这些特性使它们能够调节伤口微环境，从而在组织修复中得到广泛应用并取得显著成果。本综述阐述了几种新兴的2DNMs，如石墨烯及其衍生物、黑磷、MXenes和过渡金属二硫属化物在糖尿病伤口修复背景下的情况。此外，它阐明了2DNMs在伤口愈合治疗中的转化挑战和未来前景。总体而言，2DNMs为改善糖尿病伤口提供了一种极具前景的策略，从而为糖尿病伤口管理的诊断和治疗策略开辟了新途径。
