Department of Biosciences and Bioengineering, Indian Institute of Technology, Bombay (IITB), Powai, Mumbai 400076, India.
Centre for Research in Nano Technology & Science (CRNTS), Indian Institute of Technology, Bombay (IITB), Powai, Mumbai 400076, India.
ACS Appl Bio Mater. 2023 Nov 20;6(11):4740-4748. doi: 10.1021/acsabm.3c00506. Epub 2023 Oct 28.
Photothermal therapy (PTT) is an alternative cancer therapy with minimal side effects and higher efficiency and selectivity. In this study, WS nanosheets were developed by ultrasonic exfoliation with different ratios of polyethylene glycol (PEG), and their effects on physicochemical properties were studied. The utilization of PEG during sonication significantly influenced the size and thickness of the resulting WS nanosheet layers, which was confirmed through scanning electron microscopy, atomic force microscopy, and dynamic light scattering analyses. PEG functionalization also improved the dispersibility of WS in aqueous solution by making its surface hydrophilic, which resulted in better biocompatibility. The intrinsic near-infrared absorbance of the nanosheets positions them as valuable agents for PTT. The study further explores the efficacy of these nanosheets as photothermal agents in the ablation of MDAMB-231 breast cancer cells. Although the use of PEG to demonstrate exfoliation and biocompatibility for WS has been reported previously, the effect of PEGylation on various physicochemical properties has not been studied in-depth until now. This study paves the way for the use of highly versatile PEG across a range of 2D material systems.
光热疗法（PTT）是一种副作用极小、效率和选择性更高的癌症替代疗法。在这项研究中，通过超声剥离制备了 WS 纳米片，并研究了不同比例的聚乙二醇（PEG）对其理化性质的影响。超声过程中 PEG 的利用显著影响了所得 WS 纳米片层的尺寸和厚度，这通过扫描电子显微镜、原子力显微镜和动态光散射分析得到了证实。PEG 功能化通过使 WS 表面亲水来提高其在水溶液中的分散性，从而提高了生物相容性。纳米片的固有近红外吸收使它们成为 PTT 的有价值的试剂。该研究进一步探讨了这些纳米片作为光热剂在消融 MDAMB-231 乳腺癌细胞中的功效。尽管之前已经有报道称 PEG 用于 WS 的剥离和生物相容性，但直到现在，PEG 化对各种理化性质的影响还没有得到深入研究。这项研究为在一系列 2D 材料系统中使用多功能 PEG 铺平了道路。
