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无菌性脾脓肿伴Sweet综合征作为新发克罗恩病的肠外表现

Aseptic Splenic Abscesses With Concomitant Sweet Syndrome as Extraintestinal Manifestations of New-Onset Crohn's Disease.

作者信息

McGrath Mary, Geng Calvin, Rainho Anthony, Figueroa Esteban

机构信息

Department of Internal Medicine, University of Virginia Health, Charlottesville, VA.

Division of Gastroenterology and Hepatology, University of Virginia Health, Charlottesville, VA.

出版信息

ACG Case Rep J. 2024 Aug 29;11(9):e01464. doi: 10.14309/crj.0000000000001464. eCollection 2024 Sep.

DOI:10.14309/crj.0000000000001464
PMID:39221234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11361625/
Abstract

Splenic abscesses are typically infectious in nature but have rarely been reported as an extraintestinal manifestation of inflammatory bowel disease, particularly of Crohn's disease. In the United States, reported cases are even more scarce. We present a case of aseptic splenic abscess with concomitant Sweet syndrome in a middle-aged woman with newly diagnosed Crohn's disease. Extensive workup was required to reach final diagnosis, and she rapidly improved with corticosteroid therapy and has been maintained on risankizumab. We aim to contribute to limited data and heighten clinician awareness of these atypical extraintestinal manifestations.

摘要

脾脓肿通常具有感染性,但作为炎症性肠病,尤其是克罗恩病的肠外表现却鲜有报道。在美国,报道的病例更为稀少。我们报告一例新诊断为克罗恩病的中年女性患者,其患有无菌性脾脓肿并伴有Sweet综合征。为明确最终诊断需要进行广泛的检查,她接受皮质类固醇治疗后迅速好转,并一直使用司库奇尤单抗维持治疗。我们旨在为有限的数据提供补充,并提高临床医生对这些非典型肠外表现的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/2f8c527ba19f/ac9-11-e01464-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/132be754a4ae/ac9-11-e01464-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/3803433093ee/ac9-11-e01464-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/2f8c527ba19f/ac9-11-e01464-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/132be754a4ae/ac9-11-e01464-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/3803433093ee/ac9-11-e01464-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8350/11361625/2f8c527ba19f/ac9-11-e01464-g003.jpg

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引用本文的文献

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Epidemiologia (Basel). 2025 Aug 7;6(3):44. doi: 10.3390/epidemiologia6030044.

本文引用的文献

1
Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years' Evolution Data on a 71-Patient Series.无菌性脓肿综合征:71例患者系列的临床特征、相关疾病及长达30年的演变数据
J Clin Med. 2022 Jun 25;11(13):3669. doi: 10.3390/jcm11133669.
2
Systematic Review: Sweet Syndrome Associated with Inflammatory Bowel Disease.系统评价:Sweet 综合征与炎症性肠病相关。
J Crohns Colitis. 2021 Nov 8;15(11):1864-1876. doi: 10.1093/ecco-jcc/jjab079.
3
The Sweet syndrome as a cutaneous manifestation of Crohn's disease.
Sweet综合征作为克罗恩病的一种皮肤表现。
Proc (Bayl Univ Med Cent). 2020 Apr 23;33(3):395-397. doi: 10.1080/08998280.2020.1753457. eCollection 2020 Jul.
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Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature.无菌性脓肿和炎症性肠病:两例病例并文献复习。
Can J Gastroenterol Hepatol. 2017;2017:5124354. doi: 10.1155/2017/5124354. Epub 2017 Feb 6.
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Cutaneous manifestations in patients with inflammatory bowel diseases: pathophysiology, clinical features, and therapy.炎症性肠病患者的皮肤表现:发病机制、临床特征和治疗。
Inflamm Bowel Dis. 2014 Jan;20(1):213-27. doi: 10.1097/01.MIB.0000436959.62286.f9.
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Is splenectomy a treatment option for aseptic abscesses in patients with Crohn's disease?脾切除术是否是克罗恩病患者无菌性脓肿的治疗选择?
Eur J Gastroenterol Hepatol. 2009 Nov;21(11):1314-6. doi: 10.1097/MEG.0b013e32832bab85.
7
Aseptic abscesses: a study of 30 patients with or without inflammatory bowel disease and review of the literature.无菌性脓肿:30例伴或不伴炎症性肠病患者的研究及文献综述
Medicine (Baltimore). 2007 May;86(3):145-161. doi: 10.1097/md.0b013e18064f9f3.
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Splenic abscess. Report of 10 cases and review of the literature.脾脓肿。10例报告及文献复习。
Am J Med. 1976 Oct;61(4):513-22. doi: 10.1016/0002-9343(76)90331-4.