Toll 样受体 4（TLR4）和 Toll 样受体 2（TLR 2）基因多态性对急性非胆源性胰腺炎患者临床结局的影响。
Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients.
机构信息
General Surgery, Biruni University Hospital Organ Transplantation and Hepatobiliary Surgery Center, İstanbul, Türkiye.
Medical Genetics, Istanbul Medeniyet University Göztepe Training and Research Hospital Genetic Department, Istanbul, Türkiye.
出版信息
Front Immunol. 2024 Aug 16;15:1427187. doi: 10.3389/fimmu.2024.1427187. eCollection 2024.
INTRODUCTION
In this retrospective study, it was aimed to evaluate effects of Toll Like Receptor 4 (TLR4) and Toll Like Receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients.
METHODS
A total of 108 acute non-biliary pancreatitis patients (ANBP) were retrospectively subjected to the study. Gender, age, number of attacks, hospitalization duration, amylase, lipase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), leukocyte, C-reactive protein (CRP), total bilirubin, direct bilirubin, Atlanta score, ultrasonography (USG), Computer Tomography (CT) and patient outcome differences between TLR 4 Rs4986790, TLR 4 Rs4986791 and TLR 2 groups were evaluated.
RESULTS
According to TLR 4 Rs4986790 groups, females were significantly common in AA sequence (AA) group with statistically significant difference (p<0.05). Leukocyte mean of AG sequence (AG) group was significantly higher than of AA group (p<0.05). All parameter differences between TLR 4 Rs4986791 and TLR 2 groups were statistically insignificant (p>0.05). there was a statistically significant correlation between TLR 4 Rs4986790 and gender (r=0.265; p<0.01), Leukocyte (r=0.200; p<0.05) and Pseudocyst (r=0.203; p<0.05). TLR 4 Rs4986790 gene polymorphism had significant effect on leukocyte level in acute non-biliary pancreatitis patients (OR: -0.1.900; p<0.05). Predictive value of leukocyte for TLR 4 Rs4986790 was statistically significant (Area Under Curve: 0.624; p<0.05). For 7.65 leukocyte cut off value, sensitivity for AA gene polymorphism was 84.2% and specificity was 40.5.
CONCLUSION
Although the clinical and outcome parameters of ANBP patients in terms of TLR 4 Rs4986791 and TLR 2 do not show significant differences, research findings point to the diagnostic value of patients' leukocyte parameters in determining TLR-4 Rs4986790 ploimorphism groups.
介绍
在这项回顾性研究中，旨在评估 Toll 样受体 4（TLR4）和 Toll 样受体 2（TLR 2）基因多态性对急性非胆源性胰腺炎患者临床结局的影响。
方法
共对 108 例急性非胆源性胰腺炎患者（ANBP）进行了回顾性研究。比较 TLR4 Rs4986790、TLR4 Rs4986791 和 TLR2 组之间的性别、年龄、发作次数、住院时间、淀粉酶、脂肪酶、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、白细胞、C 反应蛋白（CRP）、总胆红素、直接胆红素、亚特兰大评分、超声（USG）、计算机断层扫描（CT）和患者结局的差异。
结果
根据 TLR4 Rs4986790 组，AA 序列（AA）组女性明显多于 AG 序列（AG）组，差异有统计学意义（p<0.05）。AG 组白细胞均值明显高于 AA 组（p<0.05）。TLR4 Rs4986791 和 TLR2 组之间所有参数差异均无统计学意义（p>0.05）。TLR4 Rs4986790 与性别（r=0.265；p<0.01）、白细胞（r=0.200；p<0.05）和假性囊肿（r=0.203；p<0.05）之间存在显著相关性。TLR4 Rs4986790 基因多态性对急性非胆源性胰腺炎患者白细胞水平有显著影响（OR：-0.1.900；p<0.05）。白细胞对 TLR4 Rs4986790 的预测价值具有统计学意义（曲线下面积：0.624；p<0.05）。对于 7.65 的白细胞截断值，AA 基因多态性的敏感性为 84.2%，特异性为 40.5%。
结论
尽管 TLR4 Rs4986791 和 TLR2 对 ANBP 患者的临床和结局参数无显著差异，但研究结果表明，患者白细胞参数在确定 TLR-4 Rs4986790 ploimorphism 组方面具有诊断价值。
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