Ianishevskaia M N
Zh Mikrobiol Epidemiol Immunobiol. 1985 Feb(2):27-32.
P. aeruginosa adsorbed toxoid has been obtained. The stabilization of exotoxins and the content of proteases, hemolysin, lecithinase in their structure have been found to enhance the immunogenic potency of preparations which protect test animals from death caused by the experimental injections of toxins, homologous and heterologous to bacterial strains of different O-serogroups, into these animals. Antibodies neutralizing the lethal action of P. aeruginosa exotoxin have been detected in the blood sera of immunized animals.
已获得铜绿假单胞菌吸附类毒素。研究发现,外毒素的稳定性以及其结构中蛋白酶、溶血素、卵磷脂酶的含量增加了制剂的免疫原性效力,这些制剂可保护实验动物免受不同O血清群细菌菌株的同源和异源毒素实验注射所致死亡。在免疫动物的血清中检测到了中和铜绿假单胞菌外毒素致死作用的抗体。