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小鼠心血管成像。

Mouse Cardiovascular Imaging.

机构信息

Division of Pediatric Cardiology, Department of Pediatrics, New York University Grossman School of Medicine, New York, New York.

Department of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging, & Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, New York.

出版信息

Curr Protoc. 2024 Sep;4(9):e1116. doi: 10.1002/cpz1.1116.

Abstract

The mouse is the mammalian model of choice for investigating cardiovascular biology, given our ability to manipulate it by genetic, pharmacologic, mechanical, and environmental means. Imaging is an important approach to phenotyping both function and structure of cardiac and vascular components. This review details commonly used imaging approaches, with a focus on echocardiography and magnetic resonance imaging, with brief overviews of other imaging modalities. In this update, we also emphasize the importance of rigor and reproducibility in imaging approaches, experimental design, and documentation. Finally, we briefly outline emerging imaging approaches but caution that reliability and validity data may be lacking. © 2024 Wiley Periodicals LLC.

摘要

鉴于我们能够通过遗传、药理学、机械和环境手段对其进行操纵,因此,老鼠是研究心血管生物学的首选哺乳动物模型。成像技术是对心脏和血管成分的功能和结构进行表型分析的重要方法。本综述详细介绍了常用的成像方法,重点介绍了超声心动图和磁共振成像,并简要介绍了其他成像方式。在本次更新中,我们还强调了在成像方法、实验设计和文件记录方面保持严格和可重复性的重要性。最后,我们简要概述了新兴的成像方法,但提醒注意可能缺乏可靠性和有效性数据。© 2024 Wiley Periodicals LLC.

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