Programa de Pós-graduação em Engenharia Biomédica, Universidade Brasil Itaquera, São Paulo, SP, 08230-030, Brazil.
Ciência & Estética Cursos, Amparo SP, Brazil.
Lasers Med Sci. 2024 Sep 2;39(1):230. doi: 10.1007/s10103-024-04182-0.
The aim of the present study was to evaluate the photothermal effects of a subdermal high-power diode laser at a wavelength (λ) of 1470 nm in the skin of rats. Twenty male Wistar rats were used, divided into 2 groups: placebo laser (PL) and active laser (AL). A high-power diode laser equipment was applied to 5 subdermal vectors on the animal's back region. The results demonstrated that active laser animals showed a better arrangement of collagen fiber bands, an increase in the thickness of the dermis and the number of vessels. Furthermore, animals treated with active laser showed an increased immunoexpression of TGF-β and VEGF compared to the placebo. The present work demonstrated that the subdermal high-power diode laser increases the vascularization and the expression of factors that enhance skin regeneration and may be promising resource in the esthetic and dermatology clinical treatment of skin rejuvenation.
本研究旨在评估 1470nm 波长的皮下高功率二极管激光在大鼠皮肤中的光热效应。使用 20 只雄性 Wistar 大鼠，分为 2 组：安慰剂激光（PL）和活性激光（AL）。将高功率二极管激光设备应用于动物背部的 5 个皮下向量。结果表明，活性激光组的胶原纤维带排列更好，真皮厚度和血管数量增加。此外，与安慰剂相比，接受活性激光治疗的动物 TGF-β和 VEGF 的免疫表达增加。本研究表明，皮下高功率二极管激光可增加血管生成和增强皮肤再生的因子表达，这可能是皮肤年轻化的美容和皮肤科临床治疗的有前途的资源。
