Wang Nanchao, Yao Junjie
IEEE Trans Ultrason Ferroelectr Freq Control. 2024 Dec;71(12: Breaking the Resolution Barrier in Ultrasound):1801-1813. doi: 10.1109/TUFFC.2024.3451986. Epub 2025 Jan 8.
Photoacoustic imaging (PAI), also known as optoacoustic imaging, is a hybrid imaging modality that combines the rich contrast of optical imaging with the deep penetration of ultrasound (US) imaging. Over the past decade, PAI has been increasingly utilized in biomedical studies, providing high-resolution high-contrast images of endogenous and exogenous chromophores in various fundamental and clinical research. However, PAI faces challenges in achieving high imaging resolution and deep tissue penetration simultaneously, limited by the optical and acoustic interactions with tissues. Overcoming these limitations is crucial for maximizing the potential of PAI for biomedical applications. Recent advances in super-resolution (SR) PAI have opened new possibilities for achieving high imaging resolution at greater depths. This review provides a comprehensive summary of these promising strategies, highlights their representative applications, envisions the potential future directions, and discusses the broader impact on biomedical imaging.
光声成像（PAI），也被称为光声成像，是一种将光学成像丰富的对比度与超声（US）成像的深度穿透性相结合的混合成像方式。在过去十年中，光声成像已越来越多地应用于生物医学研究，在各种基础和临床研究中提供内源性和外源性发色团的高分辨率高对比度图像。然而，由于与组织的光学和声学相互作用，光声成像在同时实现高成像分辨率和深部组织穿透方面面临挑战。克服这些限制对于最大限度地发挥光声成像在生物医学应用中的潜力至关重要。超分辨率（SR）光声成像的最新进展为在更大深度实现高成像分辨率开辟了新的可能性。本综述全面总结了这些有前景的策略，突出了它们的代表性应用，展望了潜在的未来方向，并讨论了对生物医学成像的更广泛影响。
