Zhang Wei, Yang Fan, Li Weichao, Ma Yuepeng, Ma Zhifang, Wang Xin, Hu Caoyang
Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Urology. 2024 Dec;194:99-104. doi: 10.1016/j.urology.2024.08.063. Epub 2024 Aug 31.
To explore the association between drugs and urinary retention using the FDA Adverse Event Reporting System (FAERs) database and Mendelian randomization (MR) analysis, providing preliminary insights into the underlying mechanisms.
Drug-adverse reaction reports from the FAERs database from 2004 to 2023 were obtained, and MR analysis was conducted to further validate the causal relationship between drugs and urinary retention using genetic data provided by the IEU OpenGWAS project.
We identified 78 drugs associated with urinary retention, including Mirabegron, Tiotropium, Quetiapine, Amlodipine, etc. MR analysis indicated genetic markers (SNPs rs10500326, rs4815689, and rs1216743) of Amlodipine were associated with an increased risk of urinary retention. Sensitivity analysis demonstrated the robustness and reliability of the results.
This study identified various drugs associated with urinary retention, particularly Amlodipine. This finding provides new clues for further investigation into the mechanisms of drug effects on bladder function and offers important references for clinical practice. However, further randomized controlled trials are needed to validate these associations and explore deeper mechanisms.
利用美国食品药品监督管理局不良事件报告系统（FAERs）数据库和孟德尔随机化（MR）分析，探讨药物与尿潴留之间的关联，为潜在机制提供初步见解。
获取2004年至2023年FAERs数据库中的药物不良反应报告，并使用IEU OpenGWAS项目提供的遗传数据进行MR分析，以进一步验证药物与尿潴留之间的因果关系。
我们确定了78种与尿潴留相关的药物，包括米拉贝隆、噻托溴铵、喹硫平、氨氯地平等。MR分析表明，氨氯地平的遗传标记（单核苷酸多态性rs10500326、rs4815689和rs1216743）与尿潴留风险增加有关。敏感性分析证明了结果的稳健性和可靠性。
本研究确定了多种与尿潴留相关的药物，尤其是氨氯地平。这一发现为进一步研究药物对膀胱功能影响的机制提供了新线索，并为临床实践提供了重要参考。然而，需要进一步的随机对照试验来验证这些关联并探索更深层次的机制。
