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艾蒿多糖的最新研究进展:提取、分离、结构特征、药理活性及应用现状和潜力。

Recent advances in Artemisia argyi Levl. et Vant. polysaccharides: Extractions, purifications, structural characteristics, pharmacological activities, and existing and potential applications.

机构信息

Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150000, China.

Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150000, China.

出版信息

Int J Biol Macromol. 2024 Nov;279(Pt 2):135250. doi: 10.1016/j.ijbiomac.2024.135250. Epub 2024 Aug 31.

Abstract

Artemisia argyi Levl. et Vant. (A. argyi) is an important member of Asteraceae (Compositae) family, which has good medicinal potential and edible value. Phytochemical studies have shown that the A. argyi has a variety of bioactive components, mainly including polysaccharides, flavonoids, alkaloids, and volatile oil. More and more evidences show that A. argyi polysaccharide is a kind of representative pharmacological and biological active macromolecules, which has a variety of pharmacological activities in vitro and in vivo, such as estrogen-like effect, anti-bacterial, anti-tumor, anti-oxidant and immune regulation effect. As far as we know, there are few comprehensively reviews on A. argyi polysaccharide. This review aims to comprehensively and systematically review the research progress on the extractions and purifications, structural characteristics, pharmacological activities, structure-activity relationships, existing and potential applications of A. argyi polysaccharides in the past 12 years, in order to support their therapeutic potential and health functions. Finally, prospects were made for the further development and utilization of A. argyi polysaccharides in four fields: food, medicine, packaging materials, and daily chemicals.

摘要

艾蒿(Artemisia argyi Levl. et Vant.)是菊科(Compositae)的重要成员,具有良好的药用潜力和食用价值。植物化学研究表明,艾蒿含有多种生物活性成分,主要包括多糖、类黄酮、生物碱和挥发油。越来越多的证据表明,艾蒿多糖是一种具有代表性的药理和生物活性的大分子,具有多种体外和体内的药理活性,如雌激素样作用、抗菌、抗肿瘤、抗氧化和免疫调节作用。据我们所知,目前对艾蒿多糖的综合研究还很少。本综述旨在全面系统地回顾过去 12 年艾蒿多糖的提取与纯化、结构特征、药理活性、构效关系、现有和潜在应用的研究进展,以支持其治疗潜力和健康功能。最后,从食品、医药、包装材料和日用化学品四个领域对艾蒿多糖的进一步开发和利用进行了展望。

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