Inpictura Ltd, 5 The Chambers, Vineyard, Abingdon OX14 3PX, United Kingdom; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, M20 4BX Manchester, United Kingdom.
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Radiother Oncol. 2024 Nov;200:110513. doi: 10.1016/j.radonc.2024.110513. Epub 2024 Sep 1.
Over the past decade, tools for automation of various sub-tasks in radiotherapy planning have been introduced, such as auto-contouring and auto-planning. The purpose of this study was to benchmark what degree of automation is possible.
A challenge to perform automated treatment planning for prostate and prostate bed radiotherapy was set up. Participants were provided with simulation CTs and a treatment prescription and were asked to use automated tools to produce a deliverable radiotherapy treatment plan with as little human intervention as possible. Plans were scored for their adherence to the protocol when assessed using consensus expert contours.
Thirteen entries were received. The top submission adhered to 81.8% of the minimum objectives across all cases using the consensus contour, meeting all objectives in one of the ten cases. The same system met 89.5% of objectives when assessed with their own auto-contours, meeting all objectives in four of the ten cases. The majority of systems used in the challenge had regulatory clearance (Auto-contouring: 82.5%, Auto-planning: 77%). Despite the 'hard' rule that participants should not check or edit contours or plans, 69% reported looking at their results before submission.
Automation of the full planning workflow from simulation CT to deliverable treatment plan is possible for prostate and prostate bed radiotherapy. While many generated plans were found to require none or minor adjustment to be regarded as clinically acceptable, the result indicated there is still a lack of trust in such systems preventing full automation.
在过去十年中,已经引入了各种放疗计划子任务的自动化工具,例如自动勾画和自动计划。本研究的目的是确定自动化的程度。
针对前列腺和前列腺床放疗的自动治疗计划设定了一项挑战。参与者提供了模拟 CT 和治疗处方,并要求他们使用自动化工具尽可能减少人为干预来生成可交付的放疗治疗计划。使用共识专家轮廓评估时,根据计划对协议的遵守程度进行评分。
共收到 13 份参赛作品。排名最高的参赛作品使用共识轮廓,在所有病例中,有 81.8%的病例符合所有最小目标,在 10 个病例中的 1 个病例中符合所有目标。同一系统使用自身的自动勾画时,有 89.5%的病例符合所有目标,在 10 个病例中的 4 个病例中符合所有目标。该挑战中使用的大多数系统都具有监管批准(自动勾画:82.5%,自动计划:77%)。尽管有“硬性”规定,即参与者不应检查或编辑轮廓或计划,但仍有 69%的人在提交前查看了他们的结果。
从模拟 CT 到可交付的治疗计划,前列腺和前列腺床放疗的全规划工作流程的自动化是可行的。虽然许多生成的计划被认为不需要或只需进行少量调整即可被认为是临床可接受的,但结果表明,人们对这些系统的信任度仍然不足,这阻碍了完全自动化。