Department of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Department of Public Health, California State University, Fullerton, CA, USA.
J Matern Fetal Neonatal Med. 2024 Dec;37(1):2397721. doi: 10.1080/14767058.2024.2397721. Epub 2024 Sep 2.
To evaluate the association between wildfire exposure in pregnancy and spina bifida risk.
This retrospective cohort study used the California Office of Statewide Health Planning and Development Linked Birth File with hospital discharge data between 2007 and 2010. The Birth File data were merged with the California Department of Forestry and Fire Protection data of the same year. Spina bifida was identified by its corresponding ICD-9 code listed on the hospital discharge of the newborn. Wildfire exposure was determined based on the zip code of the woman's home address. Pregnancy was considered exposed to wildfire if the mother lived within 15 miles of a wildfire during the pregnancy or within 30 days prior to pregnancy.
There were 2,093,185 births and 659 cases of spina bifida between 2007 and 2010. The births were analyzed using multivariable logistic regression models and adjusted for potential confounders. Exposure to wildfire in the first trimester was associated with higher odds of spina bifida (aOR= 1.43 [1.11-1.84], -value = 0.01). Wildfire exposure 30 days before the last menstrual period and during the second and third trimesters were not associated with higher spina bifida risk.
Wildfire exposure has shown an increased risk of spina bifida during the early stages of pregnancy.
评估孕期野火暴露与脊柱裂风险之间的关联。
这是一项回顾性队列研究，使用了加利福尼亚州全州卫生规划和发展办公室的出生档案，其中包含了 2007 年至 2010 年的医院出院数据。出生档案数据与当年的加利福尼亚州林业和消防局数据相合并。脊柱裂通过新生儿医院出院记录上列出的相应 ICD-9 代码进行识别。根据母亲家庭住址的邮政编码确定野火暴露情况。如果母亲在怀孕期间或怀孕前 30 天内居住在野火 15 英里范围内，则认为其怀孕时暴露于野火。
2007 年至 2010 年期间，共有 2093185 例分娩和 659 例脊柱裂病例。使用多变量逻辑回归模型对分娩进行分析，并调整了潜在的混杂因素。在孕早期暴露于野火与脊柱裂的发病风险增加相关（调整比值比[aOR]=1.43[1.11-1.84]，P 值=0.01）。末次月经前 30 天以及第二和第三个孕期暴露于野火与较高的脊柱裂风险无关。
野火暴露与妊娠早期的脊柱裂风险增加有关。
