Nosoh Y, Yoshinaka K, Yamaguchi M, Tani T, Toge T, Niimoto M, Hattori T
Gan To Kagaku Ryoho. 1984 Aug;11(8):1623-8.
Since interferon (IFN) has a mechanism of action very different from chemotherapeutic agents, it is possible that a combination of two may be of therapeutic value. The authors studied increased cytotoxic effects of anticancer drugs by IFN on human tumors xenografts in nude mice. Tumor used in this study were "SH-10", "S-7379" (gastric cancer) and "O-7294" (malignant melanoma), serially transplanted subcutaneously. IFN was injected, 5 X 10(5) mu/mouse, every day for 2 weeks and a single drug was administered 3 times every fourth day. Cytotoxic effect was determined by tumor size on day 16 after treatment. Of the 7 drugs, MMC and ADM were most effective. Other drugs showed a slight inhibition of tumor growth by combination therapy with drugs and IFN.
由于干扰素（IFN）的作用机制与化疗药物截然不同，二者联合使用可能具有治疗价值。作者研究了干扰素增强抗癌药物对裸鼠人肿瘤异种移植的细胞毒性作用。本研究中使用的肿瘤为“SH - 10”、“S - 7379”（胃癌）和“O - 7294”（恶性黑色素瘤），通过皮下连续移植。每天注射干扰素，剂量为5×10⁵ 单位/只小鼠，共注射2周，每四天单次给药一种药物，共给药3次。治疗后第16天通过肿瘤大小确定细胞毒性作用。在7种药物中，丝裂霉素（MMC）和阿霉素（ADM）最为有效。其他药物通过与药物和干扰素联合治疗对肿瘤生长有轻微抑制作用。
