2021-2022 年中国杭州儿童感染副流感病毒 1 型的流行病学和遗传特征。
Epidemiology and genetic characterization of human parainfluenza virus-1 infection in pediatric patients from Hangzhou China, 2021-2022.
机构信息
Department of Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, PR China.
Department of Stomatology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, PR China.
出版信息
Virol J. 2024 Sep 2;21(1):206. doi: 10.1186/s12985-024-02479-8.
BACKGROUND
Human parainfluenza virus-1 (HPIV-1) is a notable pathogen instigating acute respiratory tract infections in children. The article is to elucidate the epidemiological and genetic characteristics of HPIV-1 circulating in Hangzhou during the period of 2021-2022.
METHODS
A cohort of 2360 nasopharyngeal swabs were amassed and subsequently examined via RT-PCR, with HPIV-1 positive samples undergoing P gene sequencing.
RESULTS
The highest HPIV-1 infection rates were found in children aged between 3 and 6 years. A pronounced positive rate persisted through the latter half of 2021, with a notable decline observed in the initial half of 2022. All HPIV-1 strains could be clustered into 2 groups: Cluster 1, with strains similar to those found in Japan (LC764865, LC764864), and Cluster 2, with strains similar to the Beijing strain (MW575643).
CONCLUSION
In conclusion, our study contributes to the comprehensive data on the epidemiological and genetic characteristics of HPIV-1 in pediatric patients from Hangzhou, post the COVID-19 peak.
背景
人副流感病毒-1（HPIV-1）是引发儿童急性呼吸道感染的重要病原体。本文旨在阐明 2021 年至 2022 年期间杭州流行的 HPIV-1 的流行病学和遗传特征。
方法
收集了 2360 份鼻咽拭子标本，通过 RT-PCR 进行检测，HPIV-1 阳性样本进行 P 基因测序。
结果
HPIV-1 感染率最高的是 3 至 6 岁的儿童。2021 年下半年呈明显阳性率，2022 年上半年显著下降。所有 HPIV-1 株可分为 2 组：组 1，与日本株（LC764865、LC764864）相似；组 2，与北京株（MW575643）相似。
结论
综上所述，本研究为 COVID-19 高峰后杭州儿童患者的 HPIV-1 流行病学和遗传特征提供了全面的数据。
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