Department of Otolaryngology Head & Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, School of Medicine, Xi'an, Shaanxi, China.
Department of Clinical Science, Intervention and Technology, department of Otolaryngology Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.
Acta Otolaryngol. 2024 May-Jun;144(5-6):333-340. doi: 10.1080/00016489.2024.2390097. Epub 2024 Sep 2.
Recent studies proved that certain proportions of vestibular schwannoma (VS) originated other than vestibular nerve of the eighth cranial nerve.
AIMS/OBJECTIVES: Unlike air-conducted sounds (ACS) and bone-conducted vibration (BCV), galvanic vestibular stimulation (GVS) evokes vestibular evoked myogenic potentials (VEMPs) from the vestibular nerve.
Case-control study was conducted in unilateral VS patients pre-operatively. Healthy ears were controls. Patients examined ACS, BCV and GVS ocular VEMP (oVEMP) and cervical VEMP (cVEMP), caloric test, video head impulse test (vHIT), suppression head impulse paradigm (SHIMP) and pure tone audiometry (PTA).
Seven (26.9%) tumors affected left ear and 19 (73.1%) on the right( < .05). Response rates in VS group were statistically lower than control except for ACS-cVEMP ( < .05). Response rates of VEMPs in VS patients decreased with the tumor size grows. But not all BCV and GVS VEMPs disappeared in the largest tumor group. Abnormal rates of caloric test, vHIT gains and SHIMP were found.
Response rates of GVS VEMPs decreased with the residual functional nerve fibers. GVS VEMPs help to differentiating labyrinthine and retro-labyrinthine lesions. GVS combined with BCV VEMPs probably reflex the tumor origin from the eighth cranial nerve and/or the remaining vestibular function.
最近的研究证明，前庭神经鞘瘤（VS）的某些比例起源于第八颅神经的前庭神经以外。
目的/目标：与空气传导声音（ACS）和骨传导振动（BCV）不同，电刺激前庭可引起前庭诱发肌源性电位（VEMP）来自前庭神经。
对单侧 VS 患者进行术前病例对照研究。健康耳为对照组。患者检查 ACS、BCV 和 GVS 眼动 VEMP（oVEMP）和颈动 VEMP（cVEMP）、冷热试验、视频头脉冲试验（vHIT）、抑制头脉冲范式（SHIMP）和纯音听阈测试（PTA）。
7 例（26.9%）肿瘤累及左耳，19 例（73.1%）累及右耳（<0.05）。VS 组的反应率除 ACS-cVEMP 外均明显低于对照组（<0.05）。随着肿瘤体积的增大，VS 患者的 VEMPs 反应率呈下降趋势。但并非所有 BCV 和 GVS VEMPs 在最大肿瘤组中均消失。发现冷热试验、vHIT 增益和 SHIMP 异常率。
GVS VEMPs 的反应率随残余功能神经纤维的减少而降低。GVS VEMPs 有助于区分迷路和迷路后病变。GVS 结合 BCV VEMPs 可能反映肿瘤起源于第八颅神经和/或剩余的前庭功能。
