Department of Gastroenterology, Gastrointestinal Motility Laboratory, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
School of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Neurogastroenterol Motil. 2024 Nov;36(11):e14908. doi: 10.1111/nmo.14908. Epub 2024 Sep 2.
Supplementation with the Agave tequilana Weber blue variety fructans is a feasible treatment option for functional constipation (FC). However, its effects on colonic function have not yet been studied. This study assessed whole gut transit time (WGTT) and regional transit time using a wireless motility capsule (WMC) before and after supplementation with different fiber treatments in patients with FC.
A secondary analysis was performed on data collected from a randomized, double-blind clinical trial comparing agave fructans with psyllium plantago. WGTT, regional transit time, contractility, and pH were measured using WMC before and after fiber supplementation. Comparisons were performed using nonparametric tests.
Twenty patients with FC were evaluated, with a median age of 39 (25-54 years), and 18 (90%) were women. Five patients were included in each intervention group. There were no changes in WGTT or regional transit times between the groups (p > 0.05). Similarly, there were no differences in the changes experienced by regional or general contractility among the groups (p > 0.05). The cecal pH profile did not differ between the groups before and after fiber supplementation (p > 0.05). The percentages of clinical responses and consistency of bowel movements between the groups were similar.
CONCLUSIONS & INFERENCES: FC presents a clinical response to a fiber challenge, regardless of the administered intervention. However, this response was not associated with improvement in contractility or regional transit time. We speculate that there are other mechanisms by which fiber consumption may improve FC.
龙舌兰 Weber 蓝变异果聚糖的补充是功能性便秘 (FC) 的一种可行的治疗选择。然而，其对结肠功能的影响尚未得到研究。本研究使用无线动力胶囊 (WMC) 在 FC 患者补充不同纤维治疗前后评估全肠道转运时间 (WGTT) 和区域转运时间。
对一项比较龙舌兰果聚糖和车前草 Plantago psyllium 的随机、双盲临床试验中收集的数据进行二次分析。在纤维补充前后使用 WMC 测量 WGTT、区域转运时间、收缩性和 pH。使用非参数检验进行比较。
评估了 20 例 FC 患者，中位年龄 39（25-54 岁），18 例（90%）为女性。每组纳入 5 例患者。两组间 WGTT 或区域转运时间无变化（p>0.05）。同样，各组间区域或总体收缩性的变化也无差异（p>0.05）。纤维补充前后，各组间盲肠 pH 谱无差异（p>0.05）。各组间临床反应率和排便一致性相似。
FC 对纤维挑战有临床反应，而与给予的干预措施无关。然而，这种反应与收缩性或区域转运时间的改善无关。我们推测纤维摄入可能通过其他机制改善 FC。
