>From the Department of Hematology, School of Medicine, Ankara University, Ankara, Turkey.
Exp Clin Transplant. 2024 Jul;22(7):559-567. doi: 10.6002/ect.2023.0324.
During and after allogeneic hematopoietic stem cell donation, donors may experience adverse events. This situation can increase anxiety of candidate donors. Time to return to daily life routine and work, presentation of comorbid diseases in follow-up, and donor opinions are topics of interest.
We conducted a 14-question survey among related stem cell donors between January 2010 and March 2019 by telephone interview.
Of 257 related donors, 175 (68.1%) were interviewed; 87 (49.7%) were female and 88 (50.3%) were male. Among donors interviewed, 144 (82.3%) donated from only peripheral blood. After harvesting of stem cells, adverse events included hip pain (38.7%), bone pain (57.2%) during mobilization, and paresthesia (28.9%) during apheresis. After apheresis, 2 serious adverse events were reported in 2 (1.3%) female donors (1 salpingo-oophorectomy and 1 nephrectomy). Splenomegaly was observed in 1 male donor (0.7%). Among donors interviewed, 77 (44%) reported being able to perform daily activities on the same day. The shortest time to daily activity was in the peripheral blood group, and the longest was in the bone marrow group (P = .001). Among working donors, 23 (27.4%) returned to work on the same day; all were peripheral blood donors. Among donors interviewed, 114 (65.1%) wanted to volunteer to donate again. One donor (0.6%) expressed guilt after donation, and 162 (92.6%) recommended other people to be stem cell donors. During the follow-up period, musculoskeletal-joint diseases increased after donation (P = .012).
It is important to raise awareness in society about stem cell donation and to reduce the concerns among donor candidates. Although most of the adverse events after donation are temporary and mild, a few serious adverse events in donors have been observed. Stem cell donation does not cause loss of daily activity or inability to return to the work force.
在异基因造血干细胞捐献期间和之后，捐献者可能会经历不良事件。这种情况会增加候选捐献者的焦虑。恢复日常生活和工作的时间、随访中合并症的出现以及捐献者的意见都是人们感兴趣的话题。
我们通过电话访谈，于 2010 年 1 月至 2019 年 3 月期间对 257 名相关干细胞捐献者进行了一项包含 14 个问题的调查。
在 257 名相关供者中，有 175 名（68.1%）接受了访谈；其中 87 名（49.7%）为女性，88 名（50.3%）为男性。在接受访谈的供者中，有 144 名（82.3%）仅从外周血中捐献。干细胞采集后，不良事件包括髋部疼痛（38.7%）、动员期间骨痛（57.2%）和采集期间感觉异常（28.9%）。采集后，有 2 名女性供者（1 名卵巢切除术和 1 名肾切除术）报告发生 2 例严重不良事件（1.3%）。1 名男性供者（0.7%）出现脾肿大。在接受访谈的供者中，有 77 名（44%）报告能够在同一天进行日常活动。外周血组的活动时间最短，骨髓组的活动时间最长（P=.001）。在有工作的供者中，有 23 名（27.4%）在同一天返回工作岗位；他们均为外周血捐献者。在接受访谈的供者中，有 114 名（65.1%）希望再次自愿捐献。有 1 名供者（0.6%）在捐献后感到内疚，而 162 名供者（92.6%）建议其他人成为干细胞捐献者。在随访期间，供者捐献后肌肉骨骼关节疾病增加（P=.012）。
提高社会对干细胞捐献的认识并减少候选捐献者的担忧非常重要。尽管大多数捐献后的不良事件是暂时的且轻微的，但仍观察到一些捐献者发生严重不良事件。干细胞捐献不会导致日常活动丧失或无法重返工作岗位。
