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色素性光化性扁平苔藓:一例报告。

Pigmented actinic lichen planus: a case report.

机构信息

Clinic of Dermatology and Venereology, University Clinical Center of Serbia, Belgrade, Serbia.

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

出版信息

Acta Dermatovenerol Alp Pannonica Adriat. 2024 Sep;33(3):159-162.

Abstract

Actinic lichen planus (ALP) is a rare photosensitive subtype of lichen planus (LP) with four major forms recognized: annular, pigmented (melasma-like), dyschromic, and classic lichenoid. The prevalence is highest among dark-skinned younger females residing in tropical and subtropical regions. There are very few reports of ALP across Europe, with most of the cases among individuals living in warm countries or in people of Middle Eastern and Indian ancestry. We report a case of a 68-year-old white man that presented with a 9-year history of a mildly pruritic solitary hyperpigmented patch on the tip of his nose. Histopathological examination demonstrated signs of classic LP with epidermal atrophy, pigmentary incontinence, and signs of solar elastosis. Based on these findings, a diagnosis of pigmented ALP was established. Topical pimecrolimus and tretinoin along with rigorous photoprotection proved effective, with mild residual hyperpigmentation after 6 months of treatment. Many differential diagnostic possibilities should be considered for such a lesion. Nevertheless, a biopsy and correlation of histopathological and clinical findings can shorten the time from onset to a proper diagnosis. Treating both the hyperpigmented and inflammatory component of this dermatosis is necessary, as well as strict long-term photoprotection to prevent recurrences.

摘要

光化性扁平苔藓(ALP)是一种罕见的光敏感型扁平苔藓(LP)亚型,有四种主要形式:环状、色素沉着型(黄褐斑样)、色素减退型和经典苔藓样。在居住在热带和亚热带地区的深色皮肤年轻女性中,患病率最高。在欧洲,关于 ALP 的报道非常少,大多数病例发生在居住在温暖国家的人或有中东和印度血统的人身上。我们报告了一例 68 岁白人男性,他在鼻尖有一处 9 年的轻度瘙痒性孤立性色素沉着斑。组织病理学检查显示有典型 LP 的迹象,包括表皮萎缩、色素失禁和日光弹性纤维变性。根据这些发现,诊断为色素沉着性 ALP。局部使用吡美莫司和维 A 酸以及严格的光保护证明是有效的,治疗 6 个月后仍有轻度残余色素沉着。对于这种病变,应该考虑许多鉴别诊断的可能性。然而,活检和组织病理学及临床发现的相关性可以缩短从发病到确诊的时间。治疗这种皮肤病的色素沉着和炎症成分是必要的,同时还需要严格的长期光保护以防止复发。

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