经皮硝酸甘油制剂缺乏抗心绞痛特性的一种可能解释：一项超声心动图研究。
A possible explanation for the absence of anti-anginal properties of transdermal nitroglycerin units: an echocardiographic study.
作者信息
Bennett E D, Davis A L
出版信息
Br J Clin Pharmacol. 1985 Apr;19(4):435-40. doi: 10.1111/j.1365-2125.1985.tb02667.x.
The failure of clinical trials to demonstrate any anti-anginal properties of the transdermal nitroglycerin units has resulted in the re-evaluation of one such product, Transiderm-Nitro. Haemodynamic assessment following the application of 10, 20 and 40 cm2 units has been made in eight healthy volunteers over a 6 h period. Measurements of heart rate, blood pressure, stroke volume and left ventricular dimension (by 'M' mode echocardiography) were made 2 h after the application of the units. End diastolic dimension fell by 5.2% and stress by 12.6% implying a reduction in myocardial oxygen consumption. However this was offset by an increase in double product of 10.7% and in circumferential fibre shortening of 23.4%. These results imply that the doses used produce venodilatation leading to a reduction in myocardial oxygen consumption. However this is counterbalanced by the reflex induced increase in heart rate and inotropic state. It suggests therefore that much larger doses are required to produce significant anti-anginal effects.
临床试验未能证明透皮硝酸甘油制剂具有任何抗心绞痛特性，这导致了对其中一种产品Transiderm - Nitro的重新评估。在8名健康志愿者身上，于6小时内分别应用10平方厘米、20平方厘米和40平方厘米的制剂后进行了血流动力学评估。在应用制剂2小时后，测量了心率、血压、心搏量和左心室尺寸（通过“M”型超声心动图）。舒张末期尺寸下降了5.2%，应激下降了12.6%，这意味着心肌耗氧量减少。然而，这被双乘积增加10.7%和圆周纤维缩短增加23.4%所抵消。这些结果表明，所用剂量会导致静脉扩张，从而使心肌耗氧量减少。然而，这被反射性引起的心率和心肌收缩力增加所抵消。因此，这表明需要更大的剂量才能产生显著的抗心绞痛效果。
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