Bennett D, Davies A, Davis A
Br J Clin Pharmacol. 1983 Feb;15(2):173-80. doi: 10.1111/j.1365-2125.1983.tb01483.x.
In an acute study, 45 min following topical application of 9.2 mg of nitroglycerin (GTN) cream, exercise time increased by 100s ( < 0.005) and this increase persisted for 270 min. Systolic blood pressure showed a progressive fall. In the second study 1 h following application of 9.2 mg GTN cream, a significant reduction in left ventricular diastolic dimension was seen. In a subsequent chronic randomised double blind study, exercise time increased by 47 s ( < 0.05) at 6 h, following 3 weeks continual use. An increased dose for a further 3 weeks produced no further increase in exercise time; however, a significant decrease in left ventricular end diastolic dimension was seen. No evidence of pharmacological tolerance was seen, as patients continued to show a maximal response to sublingual nitroglycerin during the course of the study.
在一项急性研究中，局部应用9.2毫克硝酸甘油（GTN）乳膏45分钟后，运动时间增加了100秒（P<0.005），且这种增加持续了270分钟。收缩压呈逐渐下降趋势。在第二项研究中，应用9.2毫克GTN乳膏1小时后，左心室舒张直径显著减小。在随后的一项慢性随机双盲研究中，连续使用3周后，6小时时运动时间增加了47秒（P<0.05）。再增加剂量使用3周，运动时间未进一步增加；然而，左心室舒张末期直径显著减小。未观察到药理学耐受性的证据，因为在研究过程中患者对舌下硝酸甘油仍表现出最大反应。
