Zhan Haohong, Nong Xiaoli, Zhu Senzhi, Luo Ting, Li Tian, Cao Mingjing, Li Qi, He Zhuosen, Hu Junyan, Liu Xi
Department of Emergency Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Department of Ultrasound, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Heliyon. 2024 Aug 13;10(16):e36193. doi: 10.1016/j.heliyon.2024.e36193. eCollection 2024 Aug 30.
In clinical practice, there are few effective biomarkers for identifying non-alcoholic fatty liver disease (NAFLD). The aim of this study is to investigate the diagnostic value of γ-glutamyl transpeptidase to platelet ratio (GPR) combined with triglyceride (TG) in NAFLD.
A total of 14,415 individuals participated in the annual physical examination. Multivariate logistic regression analysis was conducted to investigate the exposure factors associated with NAFLD. Spearman's analysis was performed to assess the correlation among the exposure factors of NAFLD. Furthermore, the diagnostic efficacy of the combination of GPR and TG in NAFLD was analyzed using the receiver operating characteristic curve (ROC).
The results of the multivariate logistic regression analysis showed that BMI (OR = 1.619), Systolic Blood Pressure (SBP) (OR = 1.014), Diastolic Blood Pressure (DBP) (OR = 1.028), GPR (OR = 12.809), and TG (OR = 2.936) were all risk factors for NAFLD, while HDL-C (OR = 0.215) was a protective factor. Spearman correlation analysis revealed significant positive correlations between GPR and SBP, DBP, BMI, TG (p < 0.01), but a negative correlation between GPR and HDL-C (p < 0.01). TG was only positively correlated with GPR (p < 0.001). ROC curve analysis demonstrated that the area under the curve (AUC) of GPR combined with TG for diagnosis of NAFLD was 0.855 (95 % CI: 0.819-0.891), sensitivity was 83.45 % and specificity was 73.56 %.
This study indicated that high levels of GPR and TG were risk factors for NAFLD and demonstrated good clinical value in diagnosing NAFLD.
在临床实践中，用于识别非酒精性脂肪性肝病（NAFLD）的有效生物标志物很少。本研究旨在探讨γ-谷氨酰转肽酶与血小板比值（GPR）联合甘油三酯（TG）在NAFLD中的诊断价值。
共有14415人参加年度体检。进行多因素逻辑回归分析以研究与NAFLD相关的暴露因素。采用Spearman分析评估NAFLD暴露因素之间的相关性。此外，使用受试者工作特征曲线（ROC）分析GPR和TG联合诊断NAFLD的效能。
多因素逻辑回归分析结果显示，体重指数（BMI）（OR = 1.619）、收缩压（SBP）（OR = 1.014）、舒张压（DBP）（OR = 1.028）、GPR（OR = 12.809）和TG（OR = 2.936）均为NAFLD的危险因素，而高密度脂蛋白胆固醇（HDL-C）（OR = 0.215）为保护因素。Spearman相关性分析显示，GPR与SBP、DBP、BMI、TG之间存在显著正相关（p < 0.01），但GPR与HDL-C之间存在负相关（p < 0.01）。TG仅与GPR呈正相关（p < 0.001）。ROC曲线分析表明，GPR联合TG诊断NAFLD的曲线下面积（AUC）为0.855（95%CI：0.819 - 0.891），灵敏度为83.45%，特异度为73.56%。
本研究表明，高水平的GPR和TG是NAFLD的危险因素，在诊断NAFLD方面具有良好的临床价值。
