Li Aoqun, Li Yue, Li Xiaoqing, Tang Chunxiao, Yang Yang, Li Nan, Jin Yun
Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, 133000, China.
Key Laboratory of Tumor Pathobiology (Yanbian University), State Ethnic Affairs Commission, Yanji, 133000, China.
Heliyon. 2024 Aug 9;10(16):e36040. doi: 10.1016/j.heliyon.2024.e36040. eCollection 2024 Aug 30.
High expression of the ferritin light chain (FTL) in cancer promotes its onset and progression and is associated with tumour evolution. However, the significance of FTL in pan-cancer progression and prognosis in humans remains unclear. Therefore, we selected various bioinformatics databases to perform a pan-cancer analysis on a public dataset. Our results showed that FTL was differentially expressed in pan-cancer tissues compared to normal tissues. High FTL expression significantly correlated with the clinicopathological characteristics of patients with liver hepatocellular carcinoma (LIHC). The subsequent validation experiments confirmed these observations. Notably, our study found for the first time that FTLs are closely associated with LIHC and that FTLs have important clinical diagnostic and prognostic value for patients with LIHC. We confirmed that FTL expression was closely associated with altered DNA cycles and immune infiltration in LIHC. In conclusion, high levels of FTL expression are associated with poor prognosis in LIHC patients and are expected to be a potential prognostic and immune marker for LIHC.
铁蛋白轻链（FTL）在癌症中的高表达促进其发生和发展，并与肿瘤演变相关。然而，FTL在人类泛癌进展和预后中的意义仍不清楚。因此，我们选择了各种生物信息学数据库对一个公共数据集进行泛癌分析。我们的结果表明，与正常组织相比，FTL在泛癌组织中存在差异表达。FTL高表达与肝细胞癌（LIHC）患者的临床病理特征显著相关。随后的验证实验证实了这些观察结果。值得注意的是，我们的研究首次发现FTL与LIHC密切相关，并且FTL对LIHC患者具有重要的临床诊断和预后价值。我们证实FTL表达与LIHC中DNA周期改变和免疫浸润密切相关。总之，FTL高表达与LIHC患者的不良预后相关，有望成为LIHC的潜在预后和免疫标志物。
