成人和儿童中新冠病毒感染与流感感染的比较临床评估及风险分层：一项全面的系统评价和荟萃分析

Comparative Clinical Assessment and Risk Stratification of COVID-19 and Influenza Infections in Adults and Children: A Comprehensive Systematic Review and Meta-Analysis.

作者信息

Shaban Eman E, Yigit Yavuz, Elgassim Mohamed, Shaban Ahmed, Shaban Amira, Ameen Amin, Abdurabu Mohamed, Zaki Hany A

机构信息

Cardiology, Al Jufairi Diagnosis and Treatment, Hamad Medical Corporation, Doha, Qatar.

Department of Emergency Medicine, Hamad Medical Corporation, Doha, Qatar.

出版信息

Bull Emerg Trauma. 2024;12(2):47-57. doi: 10.30476/BEAT.2024.102205.1504.

OBJECTIVE

This study aimed to compare the clinical risks and outcomes of COVID-19 and influenza.

METHODS

The search for relevant articles was conducted using both a database search method and a manual search, which involved searching through the reference lists of articles related to the topic for additional studies. The Quality assessment was carried out using the Newcastle Ottawa tool, and the data analysis was conducted using the Review Manager Software (RevMan 5.4.1).

RESULTS

The meta-analysis results indicated that COVID-19 patients had similar lengths of hospital stays (SMD: -0.25; 95% CI: -0.60-0.11; =0.17). However, COVID-19 patients had significantly higher mortality rates (RR: 0.28; 95% CI: 0.21-0.37; <0.0001), in-hospital complications (RR: 0.57; 95% CI: 0.50-0.65; <0.00001), intensive care unit (ICU) admissions (OR: 0.48; 95% CI: 0.37-0.61; <0.00001), length of ICU stay (SMD: -0.45; 95% CI: -0.83-0.06; =0.02), and mechanical ventilation use (OR: 0.36; 95% CI: 0.28-0.46; <0.00001).

CONCLUSION

The findings suggested that COVID-19 was more severe than influenza. Therefore, "flu-like" symptoms should not be dismissed without a clear diagnosis, especially during the winter when influenza is more prevalent.

目的

本研究旨在比较新型冠状病毒肺炎（COVID-19）和流感的临床风险及结局。

方法

采用数据库检索和手工检索相结合的方式查找相关文章，其中手工检索包括查阅与该主题相关文章的参考文献列表以获取更多研究。使用纽卡斯尔-渥太华工具进行质量评估，并使用Review Manager软件（RevMan 5.4.1）进行数据分析。

结果

荟萃分析结果表明，COVID-19患者的住院时间相似（标准化均数差：-0.25；95%置信区间：-0.60至0.11；P = 0.17）。然而，COVID-19患者的死亡率显著更高（风险比：0.28；95%置信区间：0.21至0.37；P < 0.0001）、院内并发症发生率（风险比：0.57；95%置信区间：0.50至0.65；P < 0.00001）、入住重症监护病房（ICU）的比例（比值比：0.48；95%置信区间：0.37至0.61；P < 0.00001）、ICU住院时间（标准化均数差：-0.45；95%置信区间：-0.83至0.06；P = 0.02）以及机械通气使用率（比值比：0.36；95%置信区间：0.28至0.46；P < 0.00001）。