优特克单抗治疗期间克罗恩病患者的肾功能障碍：病例报告及文献综述
Renal Dysfunction in a Patient With Crohn's Disease During Ustekinumab Treatment: A Case Report and Review of the Literature.
作者信息
Wei Yuge, Ruan Gechong, Qin Yan, Bai Xiaoyin, Yang Hong
机构信息
4+4 Medical Doctor Program, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
出版信息
Curr Ther Res Clin Exp. 2024 Jul 5;101:100753. doi: 10.1016/j.curtheres.2024.100753. eCollection 2024.
Ustekinumab is a first-line drug for Crohn's disease. However, little is known about its potential adverse effects on renal function. We present the case of a 42-year-old man with Crohn's disease who developed chronic renal dysfunction during ustekinumab treatment, which resolved after discontinuing ustekinumab. The findings underscore the importance of close monitoring of renal function in patients receiving ustekinumab, particularly those with preexisting kidney disease or risk factors for renal dysfunction.
优特克单抗是治疗克罗恩病的一线药物。然而，关于其对肾功能潜在的不良影响却知之甚少。我们报告一例42岁克罗恩病男性患者，在接受优特克单抗治疗期间出现慢性肾功能不全，停用优特克单抗后肾功能恢复正常。这些发现强调了在接受优特克单抗治疗的患者中，尤其是那些已有肾脏疾病或存在肾功能不全危险因素的患者，密切监测肾功能的重要性。
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