Turk Psikiyatri Derg. 2024 Fall;35(3):245-247. doi: 10.5080/u26711.
Naltrexone is an μ opioid receptor antagonist that is used in alcohol and opiate use disorder. Naltrexone does not constitute tolerance and dependence, and cessation of the drug does not cause withdrawal symptoms. Sustained release form of naltrexone has been developed due to patient compliance issues. There is currently only one sustainedrelease form available in Turkey, which is inserted subcutaneously. In this case report, we present, a probable serious side effect of sustained release naltrexone implant. A 36 years old male with alcohol use disorder, developed a sudden clouding of consciousness one hour after the naltrexone implant application followed by anterograde amnesia in the next 8-10 hours. We were not able to detect any medical or neurological reasons for the altered mental status but after the removal of the naltrexone implant, the symptoms improved. To the best of our knowledge, this is the first case to report clouding of consciousness and anterograde amnesia after naltrexone implantation. Keywords: Naltrexone Implant, Side Effect, Alcohol Use Disorder, Lethargy, Consciousness.
纳曲酮是一种μ阿片受体拮抗剂，用于治疗酒精和阿片类药物使用障碍。纳曲酮不会导致耐受和依赖，停药也不会引起戒断症状。由于患者依从性问题，已开发出纳曲酮的缓释剂型。目前土耳其只有一种可供皮下植入的缓释剂型。在本病例报告中，我们介绍了纳曲酮植入后的一种可能的严重副作用。一名 36 岁男性，有酒精使用障碍，在植入纳曲酮后 1 小时出现意识突然模糊，随后在接下来的 8-10 小时内出现顺行性遗忘。我们未能发现任何导致精神状态改变的医学或神经学原因，但在移除纳曲酮植入物后，症状有所改善。据我们所知，这是首例报道纳曲酮植入后出现意识模糊和顺行性遗忘的病例。关键词：纳曲酮植入、副作用、酒精使用障碍、昏睡、意识。
