Xu Bowen, Du Rina, Bai Linna, Yang Kai
Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
Orthod Craniofac Res. 2025 Feb;28(1):95-103. doi: 10.1111/ocr.12853. Epub 2024 Sep 3.
Orthodontically induced inflammatory root resorption (OIIRR) is one of the most important side effects of orthodontic treatment. Low-level laser therapy (LLLT) is a useful way to reduce the orthodontic treatment duration and may have some effect on preventing and repairing OIIRR. However, the specific effects of LLLT on OIIRR remain unknown.
Our research aimed to evaluate the Dentin Sialophosphoprotein (DSPP) expression level and root resorption volume during treatment and retention to explore the role of LLLT in preventing and repairing OIIRR.
Thirty-seven 6-week-old male Sprague-Dawley rats were selected to establish an OIIRR model; the rats were divided into Group B (blank), Group F (force), Group F(LLLT) (force and LLLT), Group F+R (force and retention) and Group F+R(LLLT) (force, retention and LLLT). The root resorption volume of the distal buccal root and mesial root in the maxillary left first molar was calculated by micro-CT, and the DSPP expression level on the compression side of the periodontal ligament was analysed by immunohistochemical staining.
The resorption volume in Group F was greater than that in Group F(LLLT). For the mesial root, the volume in Group F was greater than that in Groups F+R and F+R(LLLT). For the distal buccal root, the volume in Groups F and F+R was greater than that in Group F+R(LLLT). The DSPP level in Group F(LLLT) was greater than that in Group F and there was no difference between Groups F+R and F+R(LLLT).
LLLT has a certain preventive effect and a limited reparative effect on OIIRR in rats.
正畸诱导的炎性牙根吸收（OIIRR）是正畸治疗最重要的副作用之一。低强度激光治疗（LLLT）是缩短正畸治疗疗程的一种有效方法，可能对预防和修复OIIRR有一定作用。然而，LLLT对OIIRR的具体影响尚不清楚。
本研究旨在评估治疗和保持期牙本质涎磷蛋白（DSPP）表达水平及牙根吸收量，以探讨LLLT在预防和修复OIIRR中的作用。
选取37只6周龄雄性Sprague-Dawley大鼠建立OIIRR模型；将大鼠分为B组（空白组）、F组（加力组）、F（LLLT）组（加力+LLLT组）、F+R组（加力+保持组）和F+R（LLLT）组（加力+保持+LLLT组）。通过显微CT计算上颌左侧第一磨牙远中颊根和近中根的牙根吸收量，采用免疫组织化学染色分析牙周膜受压侧DSPP表达水平。
F组的吸收量大于F（LLLT）组。对于近中根，F组的吸收量大于F+R组和F+R（LLLT）组。对于远中颊根，F组和F+R组的吸收量大于F+R（LLLT）组。F（LLLT）组的DSPP水平高于F组，F+R组和F+R（LLLT）组之间无差异。
LLLT对大鼠OIIRR有一定的预防作用，修复作用有限。
