Key Laboratory for Optoelectronic Information Perception and Instrumentation of Jiangxi Province, Nanchang Hangkong University, Nanchang, People's Republic of China.
Faculty of Artificial Intelligence in Education, Central China Normal University, Wuhan, People's Republic of China.
J Biophotonics. 2024 Nov;17(11):e202400275. doi: 10.1002/jbio.202400275. Epub 2024 Sep 3.
The elasticity of the limbus is crucial for ocular health, yet it remains inadequately explored. This study employs acoustic radiation force optical coherence elastography (ARF-OCE) to evaluate the biomechanical properties of the limbus under varying intraocular pressures. The method was validated using a heterogeneous phantom and subsequently applied to ex vivo porcine limbus samples. Elastic wave velocity at specific locations within the limbus was calculated, and the corresponding Young's modulus values were obtained. Spatial elasticity distribution maps were generated by correlating Young's modulus values with their respective locations in the two-dimensional structural images. The results indicate that ARF-OCE enhances the understanding of limbus biomechanical behavior and holds potential for diagnosing regional variations caused by ocular diseases.
角膜缘的弹性对于眼部健康至关重要，但目前对其研究仍不够充分。本研究采用声辐射力光学相干弹性成像（ARF-OCE）技术来评估在不同眼内压下角膜缘的生物力学特性。该方法使用不均匀性仿体进行了验证，随后应用于离体猪角膜缘样本。计算了角膜缘特定位置的弹性波速度，并获得了相应的杨氏模量值。通过将杨氏模量值与其在二维结构图像中的相应位置相关联，生成了空间弹性分布图谱。结果表明，ARF-OCE 增强了对角膜缘生物力学行为的理解，有望诊断眼部疾病引起的区域性变化。
