Appl Opt. 2020 Dec 1;59(34):10739-10745. doi: 10.1364/AO.406190.
Careful quantification of the changes in biomechanical properties of the iris can offer insight into the pathophysiology of some ocular diseases. However, to date there has not been much information available regarding this subject because clinical detection for iris elasticity remains challenging. To overcome this limitation, we explore, for the first time to our knowledge, the potential of measuring iris elasticity using acoustic radiation force optical coherence elastography (ARF-OCE). The resulting images and shear wave propagation, as well as the corresponding shear modulus and Young's modulus from ex vivo and in vivo rabbit models confirmed the feasibility of this method. With features of noninvasive imaging, micrometer-scale resolution, high acquisition speed and real-time processing, ARF-OCE is a promising method for reconstruction of iris elasticity and may have great potential to be applied in clinical ophthalmology with further refinement.
对虹膜生物力学特性变化的精确量化可以深入了解一些眼部疾病的病理生理学。然而，迄今为止，由于临床检测虹膜弹性仍然具有挑战性，因此这方面的信息并不多。为了克服这一局限性，我们首次探索了使用声辐射力光学相干弹性成像（ARF-OCE）测量虹膜弹性的潜力。从离体和活体兔模型获得的结果图像和剪切波传播，以及相应的剪切模量和杨氏模量，证实了该方法的可行性。ARF-OCE 具有非侵入性成像、亚微米级分辨率、高速采集和实时处理等特点，是一种很有前途的虹膜弹性重建方法，在进一步完善后，可能具有很大的临床应用潜力。
