Lim Teng Sheng, Rahman Irman Abdul, Umar Aminah, Hidzir Norsyahidah Mohd, Arkill Kenton Paul, Sharif Razinah, Jonet Mohd Anuar, Mohd Hur Munawar Kabir, Mohamed Faizal
Department of Applied Physics, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor Darul Ehsan, Malaysia.
Nuclear Technology Research Centre, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor Darul Ehsan, Malaysia.
Curr Radiopharm. 2025;18(2):81-99. doi: 10.2174/0118744710269842240825160247.
Various types of radiosensitisers have been introduced from the past until the present day for applications in the biomedical field. However, there is a lack of understanding and comparison between the various parameters introduced in addition to a lack of consensus among researchers on the optimal radiosensitiser for applications in the biomedical field.
This review aimed to investigate the usage of radiosensitisers in the biomedical field, determine their important parameters, and suggest radiosensitisers with potential among the analysed radiosensitisers.
This review has discussed several parameters for radiosensitisers, including median lethal dose, cell survival, tumour size, cell viability, Dose Enhancement Factor (DEF), Reactive Oxygen Species (ROS) concentration, radiosensitiser production complexity, radiosensitiser administration technique, and radiosensitiser toxicity. General trends regarding the development of radiosensitisers, including the types, effectiveness, and their production complexity, have also been discussed within this review article.
从过去到现在，在生物医学领域应用了各种类型的放射增敏剂。然而，除了研究人员对于生物医学领域应用的最佳放射增敏剂缺乏共识之外，对于引入的各种参数也缺乏理解和比较。
本综述旨在研究放射增敏剂在生物医学领域的应用，确定其重要参数，并在所分析的放射增敏剂中推荐具有潜力的放射增敏剂。
本综述讨论了放射增敏剂的几个参数，包括半数致死剂量、细胞存活、肿瘤大小、细胞活力、剂量增强因子（DEF）、活性氧（ROS）浓度、放射增敏剂生产复杂性、放射增敏剂给药技术以及放射增敏剂毒性。本文还讨论了放射增敏剂发展的总体趋势，包括类型、有效性及其生产复杂性。
