Kumar Naina
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar 508126, Hyderabad, Telangana, India.
Curr Protein Pept Sci. 2025;26(2):105-112. doi: 10.2174/0113892037329291240827113808.
Klotho, an anti-aging protein, plays a vital role in diverse biological functions, such as regulating calcium and vitamin D levels, preventing chronic fibrosis, acting as an antioxidant and anti-inflammatory agent, safeguarding against cardiovascular and neurodegenerative conditions, as well as exerting anti-apoptotic, anti-senescence effects. Additionally, it contributes to metabolic processes associated with diabetes and exhibits anti-cancer properties. This protein is commonly expressed in organs, such as kidneys, brain, pancreas, parathyroid glands, ovaries, and testes. Recent research has highlighted its significance in human fertility. This narrative review provides insight into the involvement of Klotho protein in male and female fertility, as well as its potential role in managing human infertility in the future. In this study, a search was conducted on literature spanning from November 1997 to June 2024 across multiple databases, including PUBMED, SCOPUS, and Google Scholar, focusing on Klotho proteins. The search utilized keywords, such as "discovery of Klotho proteins," "Biological functions of Klotho," "Klotho in female fertility," "Klotho and PCOS," "Klotho and cryopreservation," and "Klotho in male infertility." Inclusion criteria comprised full-length original or review articles, as well as abstracts, discussing the role of Klotho protein in human fertility, published in English in various peer-reviewed journals. Exclusion criteria involved articles published in languages other than English. Hence, due to its anti-aging characteristics, Klotho protein presents potential roles in male and female fertility and holds promising prospects for reproductive medicine. Further, it holds the potential to become a valuable asset in addressing infertility concerns for both males and females.
klotho是一种抗衰老蛋白，在多种生物学功能中发挥着至关重要的作用，比如调节钙和维生素D水平、预防慢性纤维化、充当抗氧化剂和抗炎剂、预防心血管疾病和神经退行性疾病，以及发挥抗凋亡、抗衰老作用。此外，它还参与与糖尿病相关的代谢过程，并具有抗癌特性。这种蛋白通常在肾脏、大脑、胰腺、甲状旁腺、卵巢和睾丸等器官中表达。最近的研究凸显了其在人类生育方面的重要性。这篇叙述性综述深入探讨了klotho蛋白在男性和女性生育中的作用，以及它未来在治疗人类不孕症方面的潜在作用。在本研究中，我们在多个数据库（包括PUBMED、SCOPUS和谷歌学术）中搜索了1997年11月至2024年6月期间的文献，重点关注klotho蛋白。搜索使用了“klotho蛋白的发现”“klotho的生物学功能”“klotho与女性生育”“klotho与多囊卵巢综合征”“klotho与冷冻保存”以及“klotho与男性不育”等关键词。纳入标准包括全长原创或综述文章以及摘要，这些文章讨论了klotho蛋白在人类生育中的作用，且以英文发表在各种同行评审期刊上。排除标准包括非英文发表的文章。因此，由于其抗衰老特性，klotho蛋白在男性和女性生育中具有潜在作用，在生殖医学领域前景广阔。此外，它有可能成为解决男性和女性不孕问题的宝贵资产。
