Xie Zhongcheng, Hou Qin, He Yinling, Xie Yushu, Mo Qinger, Wang Ziyi, Zhao Ziye, Chen Xi, Peng Tianhong, Li Liang, Xie Wei
Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Class of Clinical Medicine, University of South China, Hengyang 421001, Hunan, China.
Curr Protein Pept Sci. 2025;26(2):89-104. doi: 10.2174/0113892037315874240826112422.
Ferritin, as an iron storage protein, has the potential to inhibit ferroptosis by reducing excess intracellular free iron concentrations and lipid reactive oxygen species (ROS). An insufficient amount of ferritin is one of the conditions that can lead to ferroptosis through the Fenton reaction mediated by ferrous iron. Consequently, upregulation of ferritin at the transcriptional or posttranscriptional level may inhibit ferroptosis. In this review, we have discussed the essential role of ferritin in ferroptosis and the regulatory mechanism of ferroptosis in ferritin-deficient individuals. The description of the regulatory factors governing ferritin and its properties in regulating ferroptosis as underlying mechanisms for the pathologies of diseases will allow potential therapeutic approaches to be developed.
铁蛋白作为一种铁储存蛋白，具有通过降低细胞内过量的游离铁浓度和脂质活性氧（ROS）来抑制铁死亡的潜力。铁蛋白量不足是可通过亚铁介导的芬顿反应导致铁死亡的条件之一。因此，在转录或转录后水平上调铁蛋白可能会抑制铁死亡。在这篇综述中，我们讨论了铁蛋白在铁死亡中的重要作用以及铁蛋白缺乏个体中铁死亡的调节机制。对控制铁蛋白的调节因子及其调节铁死亡的特性作为疾病病理潜在机制的描述将有助于开发潜在的治疗方法。
