Bai Bingqing, Li Dujuan, Xu Mingyu, Liao Yingxue, Zhou Haofeng, Liu Fengyao, Li Wen, Ma Huan
Department of Cardiac Rehabilitation, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
South China University of Technology, Guangzhou, China.
ESC Heart Fail. 2025 Feb;12(1):640-648. doi: 10.1002/ehf2.15044. Epub 2024 Sep 3.
Sarcopenia is widely recognized as an age-related syndrome that involves a progressive loss of skeletal muscle mass and muscle strength. Many studies have shown that sarcopenia is associated with disease severity and exercise intolerance, as well as an independent predictor of mortality in patients with chronic heart failure. However, there is little research on the impact of sarcopenia on patients hospitalized with acute decompensated heart failure (ADHF).
This is a prospective, multicentre, observational cohort study. Enrolment of at least 500 participants adults aged over 18 years hospitalized for ADHF is planned, with a minimum of 195 cases each for patients with and without sarcopenia. Each patient is followed up for 6 months, 1 year, 2 years or until the occurrence of endpoint. The primary clinical outcome is all-cause mortality at 6 months. Other clinical outcomes of interest include cardiovascular mortality, all-cause hospitalization, heart failure hospitalization and survival time from enrolment to event occurrence. The sympathetic nervous activity, psychosocial factors, quality of life, physical function, and physical activity will be assessed and recorded at baseline. This study will examine the correlation between sarcopenia and prognosis in different subgroups of patients, and explore the additive effect of different comorbidities and sarcopenia on prognosis in patients with ADHF.
This study will provide important information and evidence on the clinical aspects of sarcopenia in patients with ADHF, potentially contributing to accurate risk stratification and optimal clinical management for patients with ADHF.
(URL: https://www.
gov); Unique identifier: NCT06298825.
肌肉减少症被广泛认为是一种与年龄相关的综合征，涉及骨骼肌质量和肌肉力量的逐渐丧失。许多研究表明，肌肉减少症与疾病严重程度和运动不耐受有关，也是慢性心力衰竭患者死亡率的独立预测因素。然而，关于肌肉减少症对急性失代偿性心力衰竭（ADHF）住院患者的影响的研究很少。
这是一项前瞻性、多中心、观察性队列研究。计划招募至少500名年龄超过18岁因ADHF住院的成年参与者，肌肉减少症患者和非肌肉减少症患者各至少195例。对每位患者进行6个月、1年、2年的随访或直至终点事件发生。主要临床结局是6个月时的全因死亡率。其他感兴趣的临床结局包括心血管死亡率、全因住院、心力衰竭住院以及从入组到事件发生的生存时间。在基线时评估并记录交感神经活动、心理社会因素、生活质量、身体功能和身体活动。本研究将检查肌肉减少症与不同亚组患者预后之间的相关性，并探讨不同合并症和肌肉减少症对ADHF患者预后的叠加效应。
本研究将提供关于ADHF患者肌肉减少症临床方面重要信息和证据，可能有助于对ADHF患者进行准确的风险分层和优化临床管理。
（网址：https://www.
gov）；唯一标识符：NCT06298825。
