通过铑（III）催化喹喔啉与炔基环丁醇之间的[3 + 2]环化反应构建含环丁烷的新型螺环骨架
The Construction of Novel Spirocyclic Frameworks with Cyclobutane through Rh(III)-Catalyzed [3 + 2]-Annulation between Quinoxalines and Alkynylcyclobutanols.
作者信息
Gang Yi-Chi, Dong Lin
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
J Org Chem. 2024 Sep 20;89(18):12912-12923. doi: 10.1021/acs.joc.4c00505. Epub 2024 Sep 3.
An effective synthesis strategy for the preparation of 1'-spiro[indene-1,2'-quinoxaline] has been developed. This involves a Rh(III)-catalyzed [3 + 2]-annulation of quinoxalines with alkynylcyclobutanols. The developed protocol offers a straightforward method for the preparation of versatile heterocyclic compounds with a four-membered ring and is compatible with a wide range of functional groups.
已开发出一种用于制备1'-螺[茚-1,2'-喹喔啉]的有效合成策略。这涉及铑(III)催化喹喔啉与炔基环丁醇的[3 + 2]环化反应。所开发的方案为制备具有四元环的多功能杂环化合物提供了一种直接的方法，并且与多种官能团兼容。
Zotero 插件