Rh(iii)催化、肼导向的 1-炔基环丁醇 C-H 官能化反应：一种构建 1H-吲唑的新策略。
Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: a new strategy for 1H-indazoles.
机构信息
College of pharmaceutical sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
出版信息
Chem Commun (Camb). 2020 Jul 11;56(54):7415-7418. doi: 10.1039/c9cc08884a. Epub 2020 Jun 2.
PMID:32484463
Abstract
Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions.
摘要
铑（III）催化的苯肼与 1-炔基环丁醇的偶联反应是通过肼导向的 C-H 官能化途径实现的。这种[4+1]环加成反应基于炔基环丁醇中 Csp-Csp 三键的断裂，为在温和的反应条件下制备各种 1H-吲唑提供了一条新途径。
Zotero 插件