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RADICAL: a rationally designed ion channel activated by ligand for chemogenetics.

作者信息

Zhang Heng, Zheng Zhiwei, Chen Xiaoying, Xu Lizhen, Guo Chen, Wang Jiawei, Cui Yihui, Yang Fan

机构信息

Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China.

Kidney Disease Center of the First Affiliated Hospital and Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 311121, China.

出版信息

Protein Cell. 2025 Feb 1;16(2):136-142. doi: 10.1093/procel/pwae048.

DOI:10.1093/procel/pwae048
PMID:39225378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786721/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ed/11786721/a8f0eccd435c/pwae048_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ed/11786721/b3b848783d2d/pwae048_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ed/11786721/a8f0eccd435c/pwae048_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ed/11786721/b3b848783d2d/pwae048_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ed/11786721/a8f0eccd435c/pwae048_fig2.jpg

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本文引用的文献

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Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons.星形胶质细胞介导腹侧被盖区多巴胺神经元的长时程突触调节。
Nat Neurosci. 2022 Dec;25(12):1639-1650. doi: 10.1038/s41593-022-01193-4. Epub 2022 Nov 17.
2
Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel.薄荷醇结合并激活瞬时受体电位 M8 离子通道的分子机制。
Nat Commun. 2020 Jul 29;11(1):3790. doi: 10.1038/s41467-020-17582-x.
3
TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors.
TRPM8 作为快速睾酮信号受体:在调节二态性性和社会行为中的作用。
FASEB J. 2020 Aug;34(8):10887-10906. doi: 10.1096/fj.202000794R. Epub 2020 Jul 1.
4
The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.先天免疫受体 TLR2/4 通过前额叶小胶质细胞的激活介导反复社交挫败应激引起的社交回避。
Neuron. 2018 Aug 8;99(3):464-479.e7. doi: 10.1016/j.neuron.2018.06.035. Epub 2018 Jul 19.
5
The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.瞬时受体电位香草酸亚型8(TRPM8)通道中内门控C端附近的区域在变构通道激活中起核心作用。
J Biol Chem. 2014 Oct 10;289(41):28579-94. doi: 10.1074/jbc.M114.577478. Epub 2014 Aug 25.
6
Chemogenetic tools to interrogate brain functions.化学遗传学工具用于研究大脑功能。
Annu Rev Neurosci. 2014;37:387-407. doi: 10.1146/annurev-neuro-071013-014048. Epub 2014 Jun 16.
7
Amygdala microcircuits controlling learned fear.控制习得性恐惧的杏仁核微回路。
Neuron. 2014 Jun 4;82(5):966-80. doi: 10.1016/j.neuron.2014.04.042.
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Quantitative analysis of TRP channel genes in mouse organs.鼠器官中 TRP 通道基因的定量分析。
Arch Pharm Res. 2012 Oct;35(10):1823-30. doi: 10.1007/s12272-012-1016-8. Epub 2012 Nov 9.
9
Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA(A) receptors in cortical pyramidal cells.病毒介导的皮层锥体神经元中唑吡坦不敏感型与唑吡坦敏感型 GABA(A) 受体的交换。
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