大鼠离体呼吸中枢对H⁺和CO₂的中枢化学敏感性
Central chemosensitivity to H+ and CO2 in the rat respiratory center in vitro.
作者信息
Harada Y, Wang Y Z, Kuno M
出版信息
Brain Res. 1985 May 6;333(2):336-9. doi: 10.1016/0006-8993(85)91588-4.
PMID:3922563
Abstract
The brainstem, cervical cord and attached phrenic nerve were excised from newborn rats and superfused in vitro. Respiratory output was measured by integration of phrenic nerve discharges. Respiratory output was enhanced by an increase in pCO2 at constant pH as well as by decreased pH with constant pCO2. It is concluded that the adequate stimulus to central chemoreceptors is not restricted only to H+.
摘要
从新生大鼠中取出脑干、颈髓及相连的膈神经，进行体外灌流。通过整合膈神经放电来测量呼吸输出。在恒定pH值时，pCO2升高可增强呼吸输出；在恒定pCO2时，pH值降低也可增强呼吸输出。由此得出结论，对中枢化学感受器的充分刺激并不局限于H⁺。
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