Heurteaux C, Garrec J P, Ripoll C, Wissocq J C, Thellier M
C R Acad Sci III. 1985;300(14):529-34.
The compartmental analysis of lithium in the mouse plasma has been performed using the stable isotopes, 6Li and 7Li, as tracers. The animals were kept under stationary conditions (concentration of total lithium in plasma maintained equal to 0.28 mM) during the experiment. The isotopic exchange, 6Li/7Li, was described to a good approximation by combining two first-order processes (characteristic parameters: 89 microM and 2.071 X 10(-3) X min-1 for the first one, and 193 microM and 2.215 X 10(-4) X min-1 for the second one). From these kinetic data, it was estimated that the lithium capacities of the plasma and of the cells were 282 and 454 nmol X ml-1, and that the unidirectional fluxes of lithium between plasma and cells and through the kidneys were 0.259 and 0.227 nmol X ml-1 X mn-1. Since the method makes use only of stable, hence harmless, isotopes, one might think of extending it to direct experimentation in man.
已使用稳定同位素6Li和7Li作为示踪剂对小鼠血浆中的锂进行了区室分析。在实验过程中，动物处于静止状态（血浆中总锂浓度保持等于0.28 mM）。通过结合两个一级过程（第一个过程的特征参数：89 microM和2.071×10(-3)×min-1，第二个过程的特征参数：193 microM和2.215×10(-4)×min-1），对同位素交换6Li/7Li进行了很好的近似描述。根据这些动力学数据，估计血浆和细胞的锂容量分别为282和454 nmol×ml-1，血浆与细胞之间以及通过肾脏的锂单向通量分别为0.259和0.227 nmol×ml-1×mn-1。由于该方法仅使用稳定的、因此无害的同位素，人们可能会考虑将其扩展到人体直接实验。
