Everts V, Aronson D C, Beertsen W
Calcif Tissue Int. 1985 Jan;37(1):25-31. doi: 10.1007/BF02557674.
Electron microscopic examination of bone biopsies obtained from two patients suffering from pycnodysostosis revealed that osteoclasts contained (sometimes large) cytoplasmic vacuoles filled with bone collagen fibrils. These vacuoles stained positive for acid phosphatase activity, thereby suggesting that bone matrix had been phagocytosed and subsequently exposed to hydrolytic enzymes of the lysosomal apparatus. Collagen-containing vacuoles were not observed in osteoclasts of individuals not suffering from this disease.
对两名患有致密性骨发育不全症患者的骨活检样本进行电子显微镜检查发现，破骨细胞含有（有时很大）充满骨胶原纤维的细胞质空泡。这些空泡酸性磷酸酶活性染色呈阳性，这表明骨基质已被吞噬，随后暴露于溶酶体的水解酶中。在未患此病个体的破骨细胞中未观察到含胶原的空泡。
