School of Materials Science & Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province, Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, China.
ACS Appl Mater Interfaces. 2024 Sep 18;16(37):49003-49012. doi: 10.1021/acsami.4c08602. Epub 2024 Sep 3.
Due to the limited efficacy and evident side effects of traditional chemotherapy drugs attributed to their lack of specificity and selectivity, novel strategies are essential for improving cancer treatment outcomes. Here, we successfully engineered FeO magnetic nanoparticles coated with zeolitic imidazolate framework-8 (ZIF-8). The resulting nanocomposite (FeO@ZIF-8) demonstrates efficient adsorption of a substantial amount of doxorubicin (DOX) due to the porous nature of ZIF-8. The drug-loaded nanoparticles, FeO@ZIF-8/DOX, exhibit significant accumulation at the tumor site in SW620 colon-cancer-bearing mice when guided by an external magnetic field. Within the acidic microenvironment of the tumor, the ZIF-8 framework collapses, releasing DOX and effectively inducing tumor cell death, thereby inhibiting cancer progression while not causing undesired side effects, as confirmed by a variety of in vitro and in vivo characterizations. In comparison to free DOX, FeO@ZIF-8/DOX nanoparticles show superior efficacy in colon cancer treatment. Our findings suggest that FeO@ZIF-8 holds promise as a carrier for small-molecule drug adsorption and its ferromagnetic properties provide drug targeting capabilities, thereby enhancing therapeutic effects on tumors at the same drug dosage. With excellent biocompatibility, FeO@ZIF-8 demonstrates potential as a drug carrier in targeted cancer chemotherapy. Our work suggests that a combination of magnetic targeting and acid-responsiveness holds great promise for advancing targeted cancer therapy in precision nanomedicine.
由于传统化疗药物的疗效有限，且副作用明显，这是由于它们缺乏特异性和选择性，因此需要新的策略来改善癌症治疗效果。在这里，我们成功地制备了 FeO 磁性纳米粒子，其表面覆盖有沸石咪唑酯骨架-8（ZIF-8）。所得的纳米复合材料（FeO@ZIF-8）由于 ZIF-8 的多孔性质，能够有效地吸附大量阿霉素（DOX）。载药的纳米粒子，FeO@ZIF-8/DOX，在 SW620 结肠癌荷瘤小鼠中在外磁场的引导下在肿瘤部位有明显的积累。在肿瘤的酸性微环境中，ZIF-8 骨架坍塌，释放 DOX，并有效地诱导肿瘤细胞死亡，从而抑制癌症进展，而不会产生不必要的副作用，这通过各种体外和体内表征得到了证实。与游离 DOX 相比，FeO@ZIF-8/DOX 纳米粒子在结肠癌治疗中表现出更好的疗效。我们的研究结果表明，FeO@ZIF-8 有望成为小分子药物吸附的载体，其铁磁性提供了药物靶向能力，从而在相同药物剂量下增强了对肿瘤的治疗效果。FeO@ZIF-8 具有良好的生物相容性，有望成为靶向癌症化疗的药物载体。我们的工作表明，磁靶向和酸响应性的结合在精准纳米医学中具有很大的潜力，可用于推进靶向癌症治疗。
